Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults

Table 3

Hazard ratios (HR) for the development of diabetes by different cutoff points of 1-hour PG and 2-hour PG.

Cutoff point	Sensitivity (%)	Specificity (%)	Crude HR (95% CI)	Adjusted HR (95% CI)
				Model 1	Model 2	Model 3
1-hour PG ≥155 mg/dL (8.6 mmol/L) (yes versus no)	92.9	60.3	18.2 (8.9–37.4)	7.7 (3.6–16.3)	5.9 (2.7–12.7)	5.1 (2.2–11.8)
1-hour PG ≥180 mg/dL (10.0 mmol/L) (yes versus no)	83.0	78.3	15.9 (9.7–26.0)	6.8 (3.9–11.9)	5.2 (2.9–9.4)	4.3 (2.3–8.1)
2-hour PG ≥140 mg/dL (7.8 mmol/L) (yes versus no)	60.7	83.4	7.3 (5.0–10.8)	3.1 (2.0–4.8)	1.6 (1.0–2.6)	1.6 (1.0–2.6)

Model 1: adjusted for age, sex, body mass index, fasting PG, HbA1c, smoking status, alcohol use, taking antihypertensive drugs, and taking lipid-lowering drugs. Model 2: adjusted for Model 1 variables plus the other PG (i.e., 2-hour PG for cutoff of 1-hour PG and 1-hour PG for cutoff of 2-hour PG). Model 3: adjusted for Model 2 variables plus insulinogenic index and HOMA index.