Journal of Diabetes Research

Research Article

Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy

Table 3

Fold change of the urinary glycopatterns based upon ratio of the NFIs of each lectin between DN groups and NDRD.


Lectin name	Specificity	Fold
Lectin name	Specificity	DN group I/MN	DN group I/IgAN	DN group II/MN	DN group II/IgAN

Jacalin	Galβ1-3GalNAcα-Ser/Thr(T), GalNAcα-Ser/Thr(Tn)		—		—

MAL-II	Siaα2-3Galβ1-4Glc(NAc)/Glc,			—	—

PTL-I	GalNAc, GalNAcα-1,3Gal, GalNAcα-1,3Galβ-1,3/4Glc			—	—

SJA	Terminal in GalNAc and Gal, anti-A and anti-B human blood group			—	—

AAL	α-Fuc, Fucα1-6 GlcNAc (core fucose)			—

DBA	αGalNAc, Tn antigen, GalNAcα1-3((Fucα1-2))Gal (blood group A antigen)			—	—

RCA120	β-Gal, Galβ-1,4GlcNAc (type II), Galβ1-3GlcNAc (type I)

STL	, core (GlcNAc) of N-glycan

BS-I	α-Gal/GalNAc, Galα-1,3Gal

ConA	High-Mannose, Manα1-6(Manα1-3)Man, terminal GlcNAc	—	—

PTL-II	Gal, blood group H, T-antigen			—	—

DSA	(β-1,4)-linked GlcNAc	—		—

SBA	α- or β-linked terminal GalNAc, (GalNAc)_n, GalNAcα1-3Gal, blood-group A			—

PSA	Fucα-1,6GlcNAc, α-D-Man, α-D-Glc				—

UEA-I	Fucα1-2Galβ1-4Glc(NAc)		—		—

PWM	(GlcNAc)_n, branched (LacNAc)_n		1.20

GNA	Manα1-3Man	1.49		0.73

PHA-E + L	Bisecting GlcNAc, biantennary N-glycans, tri- and tetra-antennary complex-type N-glycan		—	—	—

SNA	Sia2-6Gal/GalNAc	1.00	1.80

changes of lectins bound to DN groups compared to NDRD calculated with mean value of normalized florescence intensities of lectins obtained from 3 biological reduplicates. —, no significant difference; /, the fold-change was infinite; 0, the numerator of the fold-change was zero. versus ; versus ; versus , value was calculate by Student’s -test.