The Preferential Impairment of Pupil Constriction Stimulated by Blue Light in Patients with Type 2 Diabetes without Autonomic Neuropathy

Table 3

Corneal nerve fiber measures in control subjects and subgroups of type 2 diabetic patients stratified by the severity of neuropathy.

	Control; subjects	Type 2 diabetic patients staged by neuropathy severity
		Stage I	Stage II	Stage III
Corneal nerve fiber density (no/mm^2)	30.6–34.1	25.6–29.4	24.9–28.1	21.6–25.7
Corneal nerve fiber length (mm/mm^2)	12.1–13.3	10.6–12.0	10.1–11.5	8.95–10.4
Corneal nerve branch density (no/mm^2)	12.0–15.6	10.7–13.0	8.7–11.2	8.4–11.0
Corneal nerve branch length (mm/mm^2)	2.43–3.08	2.31–2.78	2.03–2.64	2.01–2.75
Tortuosity grade	1.86–2.04	2.40–2.64	2.39–2.58	2.47–2.68
Beading frequency (no/0.1 mm)	23.5–24.6	19.3–20.7	19.2–20.4	19.5–20.8
Bead size (µm^2)	7.89–8.25	9.80–10.2	9.90–10.3	10.0–10.4

Data are the 95% confidence intervals in control subjects and the subgroups of the type 2 diabetic patients stratified by the stages of the neuropathy according to the criteria of the Diabetic Neuropathy Study Group in Japan [14]. compared with control subjects, compared with control subjects, and compared with patients at stage I neuropathy.