The Increased Circulating Plasma Levels of Vascular Endothelial Growth Factor in Patients with Type 1 Diabetes Do Not Correlate to Metabolic Control

Table 1

Descriptive data for all study participants. The healthy controls and patients with type 1 diabetes (T1D) were matched regarding age, gender distribution, and BMI. The fasting levels of plasma glucose and HbA1c were, as expected, increased in the T1D patients. All values are given as mean ± SEM. An unpaired two-tailed -test based on ranks (Mann–Whitney) was used to compare differences between the two groups for data that were not normally distributed (a) and a two-tailed unpaired student’s -test was used for normally distributed data (b).

Parameter	Healthy controls	Type 1 diabetes	value
Total number,	45	115
Male, (%)	20 (44%)	50 (43%)
Age (years)	37.4 ± 2.7	40.2 ± 1.5	Ns (a)
Age of onset (years)	N/A	14.6 ± 0.8	N/A
Disease duration (years)	N/A	25.6 ± 1.3	N/A
BMI (kg/m^2)	25.5 ± 0.9	25 ± 0.3	Ns (a)
Fasting p-glucose (mmol/l)	5.5 ± 0.1	10.8 ± 0.5	<0.0001 (a)
HbA1c (mmol/mol, %)	35.9 ± 0.8; (5.4 ± 0.07%)	62.3 ± 1.1; (7.9 ± 0.1%)	<0.0001 (a)
P-cholesterol (mmol/l)	5.3 ± 0.3	4.7 ± 0.1	Ns (a)
P-HDL cholesterol (mmol/l)	1.4 ± 0.06	1.5 ± 0.04	Ns (b)
P-LDL cholesterol (mmol/l)	3.3 ± 0.2	2.6 ± 0.08	<0.001 (b)
P-triglycerides (mmol/l)	1.3 ± 0.1	1.0 ± 0.05	Ns (a)
P-creatinine (µmol/l)	75.1 ± 2.1	78 ± 2.4	Ns (a)
Estimated GFR (ml/min)	91.2 ± 3.4	92.8 ± 2.2	Ns (b)