Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients

Table 3

Odds ratios and 95% confidence interval for ischemic stroke under three genetic models.

	Genetic models	Unadjusted		Adjusted		Adjusted
		OR (95% CI)		OR (95% CI)		OR (95% CI)
MTHFR	Additive	1.39 (1.10–1.74)	.005	1.40 (1.11–1.77)	.005	1.42 (1.11–1.81)	.004
	Dominant	1.62 (1.06–2.48)	.027	1.60 (1.04–2.48)	.033	1.62 (1.04–2.52)	.034
	Recessive	1.51 (1.07–2.11)	.017	1.56 (1.10–2.20)	.012	1.60 (1.12–2.29)	.01
	CT versus CC	1.42 (0.90–2.23)	.135	1.38 (0.87–2.20)	.173	1.37 (0.86–2.21)	.189
	TT versus CC	1.93 (1.20–3.10)	.006	1.96 (1.21–3.17)	.006	2.00 (1.22–3.29)	.006
EPHX2	Additive	0.75 (0.55–0.95)	.02	0.72 (0.54–0.95)	.02	0.72 (0.55–0.97)	.031
	Dominant	0.67 (0.48–0.93)	.016	0.65 (0.47–0.91)	.012	0.67 (0.48–0.95)	.023
	Recessive	0.72 (0.36–1.45)	.36	0.75 (0.37–1.52)	.418	0.74 (0.36–1.56)	.432
	GA versus GG	0.68 (0.48–0.95)	.025	0.65 (0.46–0.93)	.018	0.68 (0.47–0.97)	.033
	AA versus GG	0.62 (0.30–1.26)	.182	0.63 (0.31–1.30)	.21	0.64 (0.30–1.35)	.239

CI, confidence interval; OR, odds ratio.
Adjusted for age and sex.
Adjusted for age, sex, BMI, history of hypertension, TC, TG, and HDL-C.