Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients

Table 4

Odds ratios and 95% confidence interval for the combined effect of MTHFR C677T and EPHX2 G860A polymorphism and ischemic stroke.

Genotype		Ischemic stroke	Control	Unadjusted		Adjusted		Adjusted
EPHX2	MTHFR	236	390	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
GG	CC	25	40	2.73 (1.20–6.22)	.017	2.63 (1.13–6.12)	.024	2.38 (1.00–5.65)	.049
GG	CT	70	98	3.12 (1.51–6.43)	.002	3.12 (1.49–6.53)	.003	2.92 (1.37–6.22)	.005
GG	TT	50	63	3.46 (1.63–7.35)	.001	3.41 (1.58–7.35)	.002	3.32 (1.51–7.29)	.003
GA + AA	CC	11	48	1 (Ref)		1 (Ref)		1 (Ref)
GA + AA	CT	36	85	1.84 (0.86–3.96)	.114	1.67 (0.77–3.62)	.198	1.60 (0.72–3.55)	.246
GA + AA	TT	44	56	3.42 (1.60–7.37)	.002	3.47 (1.59–7.59)	.002	3.37 (1.51–7.50)	.003

Adjusted for age and sex.
Adjusted for age, sex, BMI, history of hypertension, TC, TG, and HDL-C.