PGC1α Activators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control

Figure 8

PGC1α activators attenuate renal expression of apoptogenic and fibrotic proteins in STZ-induced diabetic mice. (a) In diabetic kidneys, the protein expression of the antiapoptotic protein Bcl2 was markedly decreased, whereas the expression of the apoptogenic proteins Bax and cytochrome C (Cyt C) increased greatly. PGC1α treatment reversed the expression of these apoptogenic-related proteins. (b) Increased expression levels of TGFβ1 and αSMA were seen in the kidneys from the diabetic group, and reduced expression levels of these proteins were seen in the AICAR- and metformin-treated groups. ( versus normal; versus diabetic control).

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