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Journal of Diabetes Research
Volume 2017 (2017), Article ID 6494795, 6 pages
Review Article

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

1College of Health Science & Nursing, Wuhan Polytechnic University, Wuhan, Hubei, China
2Cardiovascular Research Institute, Case Western Reserve University, Cleveland, OH, USA

Correspondence should be addressed to Jixin Zhong

Received 23 July 2016; Revised 30 December 2016; Accepted 12 January 2017; Published 31 January 2017

Academic Editor: Monica Bullo

Copyright © 2017 Chang Xia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.