Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2017, Article ID 6726901, 6 pages
https://doi.org/10.1155/2017/6726901
Research Article

Forkhead Protein FoxO1 Acts as a Repressor to Inhibit Cell Differentiation in Human Fetal Pancreatic Progenitor Cells

1Shenzhen University Diabetes Institute, Shenzhen University, Shenzhen 518060, China
2Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China
3Shenzhen Hightide Biopharmaceutical Ltd., Shenzhen 518000, China
4Department of Aging Medicine, The Sixth Hospital of Shenzhen Municipality, Shenzhen 518060, China

Correspondence should be addressed to Xiaosong Ma; nc.ude.uzs@amsx

Received 13 October 2016; Revised 27 December 2016; Accepted 29 January 2017; Published 28 February 2017

Academic Editor: Andrea Tura

Copyright © 2017 Zongzhe Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. A. Fridell, J. Rogers, and R. J. Stratta, “The pancreas allograft donor: current status, controversies, and challenges for the future,” Clinical Transplantation, vol. 24, no. 4, pp. 433–449, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. Z.-X. Yao, M.-L. Qin, J.-J. Liu, X.-S. Chen, and D.-S. Zhou, “In vitro cultivation of human fetal pancreatic ductal stem cells and their differentiation into insulin-producing cells,” World Journal of Gastroenterology, vol. 10, no. 10, pp. 1452–1456, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. W.-J. Zhang, S.-Q. Xu, H.-Q. Cai et al., “Evaluation of islets derived from human fetal pancreatic progenitor cells in diabetes treatment,” Stem Cell Research and Therapy, vol. 4, no. 6, article 141, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. S. C. Talchai and D. Accili, “Legacy effect of foxo1 in pancreatic endocrine progenitors on adult β-cell mass and function,” Diabetes, vol. 64, no. 8, pp. 2868–2879, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Kitamura, J. Nakae, Y. Kitamura et al., “The forkhead transcription factor Foxo1 links insulin signaling to Pdx1regulation of pancreatic β cell growth,” Journal of Clinical Investigation, vol. 110, no. 12, pp. 1839–1847, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Buteau and D. Accili, “Regulation of pancreatic β-cell function by the forkhead protein FoxO1,” Diabetes, Obesity and Metabolism, vol. 9, no. 2, pp. 140–146, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Kitamura and Y. I. Kitamura, “Role of FoxO proteins in pancreatic β cells,” Endocrine Journal, vol. 54, no. 4, pp. 507–515, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Kitamura, Y. I. Kitamura, M. Kobayashi et al., “Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1,” Molecular and Cellular Biology, vol. 29, no. 16, pp. 4417–4430, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Talchai, S. Xuan, T. Kitamura, R. A. DePinho, and D. Accili, “Generation of functional insulin-producing cells in the gut by Foxo1 ablation,” Nature Genetics, vol. 44, no. 4, pp. 406–412, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Nakae, W. H. Biggs III, T. Kitamura et al., “Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor FoxO1,” Nature Genetics, vol. 32, no. 2, pp. 245–253, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. H.-J. Kim, M. Kobayashi, T. Sasaki et al., “Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance,” Endocrinology, vol. 153, no. 2, pp. 659–671, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Niwa, J.-I. Miyazaki, and A. G. Smith, “Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells,” Nature Genetics, vol. 24, no. 4, pp. 372–376, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Mitsui, Y. Tokuzawa, H. Itoh et al., “The homeoprotein nanog is required for maintenance of pluripotency in mouse epiblast and ES cells,” Cell, vol. 113, no. 5, pp. 631–642, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Nagashima, N. Shigematsu, R. Maruki et al., “Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice,” Molecular Pharmacology, vol. 78, no. 5, pp. 961–970, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Kobayashi, “The current status of islet transplantation and its perspectives,” Review of Diabetic Studies, vol. 5, no. 3, pp. 136–143, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. M. V. Joglekar, V. M. Joglekar, S. V. Joglekar, and A. A. Hardikar, “Human fetal pancreatic insulin-producing cells proliferate in vitro,” Journal of Endocrinology, vol. 201, no. 1, pp. 27–36, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Al-Masri, M. Krishnamurthy, J. Li et al., “Effect of forkhead box O1 (FOXO1) on beta cell development in the human fetal pancreas,” Diabetologia, vol. 53, no. 4, pp. 699–711, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Furuyama, T. Nakazawa, I. Nakano, and N. Mori, “Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues,” Biochemical Journal, vol. 349, no. 2, pp. 629–634, 2000. View at Publisher · View at Google Scholar · View at Scopus