Journal of Diabetes Research / 2017 / Article / Tab 3

Research Article

Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension

Table 3

Circulating hormones, cytokines, and metabolic parameters.

Baseline values6 months after RDN value value value value
BasalClampBasalClampDifference between basal and clamp values at baselineDifference between basal and clamp values 6 months after RDNDifference between basal values at baseline and 6 months after RDNDifference between clamp values at baseline and 6 months after RDN

-value (mg/kg/min)2.68 ± 0.283.07 ± 0.410.12
P-C-peptide (pmol/l)795.0 ± 121.8466.0 ± 89.86920.4 ± 209.7529.3 ± 124.70.0010.0090.320.18
P-glucagon (pg/ml)67.13 ± 5.8148.63 ± 4.3565.50 ± 6.9945.88 ± 4.36<0.001<0.0010.730.47
P-FFA (mmol/l)0.52 ± 0.050.06 ± 0.0090.53 ± 0.070.05 ± 0.012<0.001<0.0010.880.14
P-insulin (pmol/l)81.88 ± 13.41500.0 ± 63.5392.50 ± 11.56495.8 ± 75.51<0.0010.0080.200.88
P-cortisol (ng/ml)137.3 ± 15.72145.6 ± 15.530.46
IGF-I (ng/ml)124.3 ± 9.79132.8 ± 12.210.14
Adiponectin (mg/l)12.94 ± 0.7912.72 ± 1.160.64
hsCRP (mg/l)4.60 ± 1.284.99 ± 1.140.65
TNF-α (pg/ml)4.62 ± 0.935.21 ± 0.810.21
IL-6 (pg/ml)0.64 ± 0.110.67 ± 0.090.78
IL-1β (pg/ml)0.04 ± 0.0060.05 ± 0.010.15
EGP (mg/kg/min)1.73 ± 0.160.62 ± 0.141.36 ± 0.190.36 ± 0.280.0020.0040.270.52
EE (kcal)1950 ± 1081917 ± 1141901 ± 1051881 ± 960.190.480.430.53
RQ0.82 ± 0.010.88 ± 0.010.84 ± 0.010.88 ± 0.020.0070.030.431.00
Glucose oxidation. (mg/kg/min)1.11 ± 0.211.58 ± 0.131.31 ± 0.280.92 ± 0.210.060.220.620.018
Protein oxidation (mg/kg/min)0.69 ± 0.050.67 ± 0.050.74 (0.65;1.09)0.86 (0.59;0.94)0.981.00.260.36
Lipid oxidation (mg/kg/min)0.65 ± 0.060.42 ± 0.080.55 ± 0.050.78 ± 0.120.0020.190.290.06

Basal is at time = 0 min except for EGP (endogenous glucose production), where basal is at time = 120 min; clamp is at time = 240 min. All data are presented as means with SE or median (range).

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