Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension
Table 3
Circulating hormones, cytokines, and metabolic parameters.
Baseline values
6 months after RDN
value
value
value
value
Basal
Clamp
Basal
Clamp
Difference between basal and clamp values at baseline
Difference between basal and clamp values 6 months after RDN
Difference between basal values at baseline and 6 months after RDN
Difference between clamp values at baseline and 6 months after RDN
-value (mg/kg/min)
2.68 ± 0.28
3.07 ± 0.41
0.12
P-C-peptide (pmol/l)
795.0 ± 121.8
466.0 ± 89.86
920.4 ± 209.7
529.3 ± 124.7
0.001
0.009
0.32
0.18
P-glucagon (pg/ml)
67.13 ± 5.81
48.63 ± 4.35
65.50 ± 6.99
45.88 ± 4.36
<0.001
<0.001
0.73
0.47
P-FFA (mmol/l)
0.52 ± 0.05
0.06 ± 0.009
0.53 ± 0.07
0.05 ± 0.012
<0.001
<0.001
0.88
0.14
P-insulin (pmol/l)
81.88 ± 13.41
500.0 ± 63.53
92.50 ± 11.56
495.8 ± 75.51
<0.001
0.008
0.20
0.88
P-cortisol (ng/ml)
137.3 ± 15.72
145.6 ± 15.53
0.46
IGF-I (ng/ml)
124.3 ± 9.79
132.8 ± 12.21
0.14
Adiponectin (mg/l)
12.94 ± 0.79
12.72 ± 1.16
0.64
hsCRP (mg/l)
4.60 ± 1.28
4.99 ± 1.14
0.65
TNF-α (pg/ml)
4.62 ± 0.93
5.21 ± 0.81
0.21
IL-6 (pg/ml)
0.64 ± 0.11
0.67 ± 0.09
0.78
IL-1β (pg/ml)
0.04 ± 0.006
0.05 ± 0.01
0.15
EGP (mg/kg/min)
1.73 ± 0.16
0.62 ± 0.14
1.36 ± 0.19
0.36 ± 0.28
0.002
0.004
0.27
0.52
EE (kcal)
1950 ± 108
1917 ± 114
1901 ± 105
1881 ± 96
0.19
0.48
0.43
0.53
RQ
0.82 ± 0.01
0.88 ± 0.01
0.84 ± 0.01
0.88 ± 0.02
0.007
0.03
0.43
1.00
Glucose oxidation. (mg/kg/min)
1.11 ± 0.21
1.58 ± 0.13
1.31 ± 0.28
0.92 ± 0.21
0.06
0.22
0.62
0.018
Protein oxidation (mg/kg/min)
0.69 ± 0.05
0.67 ± 0.05
0.74 (0.65;1.09)
0.86 (0.59;0.94)
0.98
1.0
0.26
0.36
Lipid oxidation (mg/kg/min)
0.65 ± 0.06
0.42 ± 0.08
0.55 ± 0.05
0.78 ± 0.12
0.002
0.19
0.29
0.06
Basal is at time = 0 min except for EGP (endogenous glucose production), where basal is at time = 120 min; clamp is at time = 240 min. All data are presented as means with SE or median (range).
