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Journal of Diabetes Research
Volume 2017, Article ID 6924637, 6 pages
Research Article

Fulminant Type 1 Diabetes in Children: A Multicenter Study in China

1National Key Discipline of Pediatrics, Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
2Department of Microbiology and Immunology, Dartmouth College, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
3Department of Endocrinology, Children’s Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai 200062, China
4Department of Endocrinology and Genetic Metabolism, Zhengzhou Children’s Hospital, Zhengzhou 450053, China
5Department of Endocrinology, Children’s Hospital of Soochow University, Suzhou 215003, China
6Department of Endocrinology, Nanjing Children’s Hospital of Nanjing Medical University, Nanjing 210005, China
7Department of Endocrinology, Genetics and Metabolism, The Children’s Hospital of Guiyang City, Guiyang 550003, China
8Department of Pediatric, Liaocheng Children’s Hospital, Shandong 252002, China
9The Pediatric Endocrine Department, Chengdu Woman and Children’s Center Hospital, Chengdu 610091, China
10Department of Pediatric, General Hospital of Ningxia Medical University, Yinchuan 750004, China

Correspondence should be addressed to Chunxiu Gong; moc.anis@gnoguixnuhc

Received 30 December 2016; Revised 18 April 2017; Accepted 17 May 2017; Published 26 September 2017

Academic Editor: Ruozhi Zhao

Copyright © 2017 Yi Gu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. Methods. A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3. Results. The incidence of FT1D was 1.56% in 16 participating hospitals. The mean age at the onset of group 1 was 2.00 (1.08, 6.51) years old, much younger than that of group 2 (6.11 (3.92, 9.50)) and group 3 (6.92 (4.17, 10.03)). In addition, significant differences were found between three groups: mean BMI and flu-like symptoms with fever and abdominal pain. Follow-up comparison of three groups from Beijing Children’s Hospital for at least one year showed that there is no significant difference between the three groups in terms of mean HbA1c levels and insulin injection dosages. Conclusion. FT1D onset age is much younger than that of classical T1D patients. The hospital-based incidence of FT1D in Chinese children was 1.56% in all new-onset T1DM. For the diagnosis, making FT1D alone into a subtype within type 1 diabetes may be meaningful. However, for the treatment and prognosis, such classification should not be helpful to the clinic.