Table of Contents Author Guidelines Submit a Manuscript
Corrigendum

A corrigendum for this article has been published. To view the corrigendum, please click here.

Journal of Diabetes Research
Volume 2017, Article ID 6978984, 10 pages
https://doi.org/10.1155/2017/6978984
Research Article

Urinary Exosomal MicroRNA Profiling in Incipient Type 2 Diabetic Kidney Disease

Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China

Correspondence should be addressed to Yaoming Xue; moc.621@999gnimoayeux

Received 2 May 2017; Revised 19 June 2017; Accepted 28 June 2017; Published 5 September 2017

Academic Editor: Ahmed A. Elmarakby

Copyright © 2017 Yijun Xie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. KDOQI, “Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease,” American Journal of Kidney Diseases, vol. 47, pp. S11–S145, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Lu, W. Gong, Z. Yang et al., “An evaluation of the diabetic kidney disease definition in Chinese patients diagnosed with type 2 diabetes mellitus,” The Journal of International Medical Research, vol. 37, pp. 1493–1500, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. L. F. Fried and J. Lewis, “Rebuttal of the pro view: albuminuria is an appropriate therapeutic target in patients with CKD,” Clinical Journal of the American Society of Nephrology, vol. 10, pp. 1095–1098, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. R. W. Carthew and E. J. Sontheimer, “Origins and mechanisms of miRNAs and siRNAs,” Cell, vol. 136, pp. 642–655, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. F. P. Schena, G. Serino, and F. Sallustio, “MicroRNAs in kidney diseases: new promising biomarkers for diagnosis and monitoring,” Nephrology, Dialysis, Transplantation, vol. 29, pp. 755–763, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Chandrasekaran, D. S. Karolina, S. Sepramaniam et al., “Role of microRNAs in kidney homeostasis and disease,” Kidney International, vol. 81, pp. 617–627, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Osipova, D. C. Fischer, S. Dangwal et al., “Diabetes-associated microRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study,” The Journal of Clinical Endocrinology and Metabolism, vol. 99, pp. E1661–E1665, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Wang, B. C. Kwan, F. M. Lai, K. M. Chow, L. P. Kam-Tao, and C. C. Szeto, “Expression of microRNAs in the urinary sediment of patients with IgA nephropathy,” Disease Markers, vol. 28, pp. 79–86, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Luo, C. Wang, X. Chen et al., “Increased serum and urinary microRNAs in children with idiopathic nephrotic syndrome,” Clinical Chemistry, vol. 59, pp. 658–666, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Wang, L. S. Tam, E. K. Li et al., “Serum and urinary free microRNA level in patients with systemic lupus erythematosus,” Lupus, vol. 20, pp. 493–500, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Argyropoulos, K. Wang, J. Bernardo et al., “Urinary microRNA profiling predicts the development of microalbuminuria in patients with type 1 diabetes,” Journal of Clinical Medicine, vol. 4, pp. 1498–1517, 2015. View at Google Scholar
  12. J. A. Weber, D. H. Baxter, S. Zhang et al., “The microRNA spectrum in 12 body fluids,” Clinical Chemistry, vol. 56, pp. 1733–1741, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. A. K. Ludwig and B. Giebel, “Exosomes: small vesicles participating in intercellular communication,” The International Journal of Biochemistry & Cell Biology, vol. 44, pp. 11–15, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. C. S. Neal, M. Z. Michael, L. K. Pimlott, T. Y. Yong, J. Y. Li, and J. M. Gleadle, “Circulating microRNA expression is reduced in chronic kidney disease,” Nephrology, Dialysis, Transplantation, vol. 26, pp. 3794–3802, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Ramezani, J. M. Devaney, S. Cohen et al., “Circulating and urinary microRNA profile in focal segmental glomerulosclerosis: a pilot study,” European Journal of Clinical Investigation, vol. 45, pp. 394–404, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Barutta, M. Tricarico, A. Corbelli et al., “Urinary exosomal microRNAs in incipient diabetic nephropathy,” PLoS One, vol. 8, article e73798, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. B. Wang, M. Herman-Edelstein, P. Koh et al., “E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-β,” Diabetes, vol. 59, pp. 1794–1802, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Argyropoulos, K. Wang, S. Mcclarty et al., “Urinary microRNA profiling in the nephropathy of type 1 diabetes,” PLoS One, vol. 8, article e54662, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Delić, C. Eisele, R. Schmid et al., “Urinary Exosomal miRNA signature in type II diabetic nephropathy patients,” PLoS One, vol. 11, article e150154, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Jia, M. Guan, Z. Zheng et al., “miRNAs in urine extracellular vesicles as predictors of early-stage diabetic nephropathy,” Journal of Diabetes Research, vol. 2016, Article ID 7932765, 10 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. M. C. Riella, “Kidney disease: Improving global outcomes (KDIGO) CKD work group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease,” Kidney International Supplements 3.1, pp. 1–150, 2013. View at Google Scholar
  22. R. Khurana, G. Ranches, S. Schafferer et al., “Identification of urinary exosomal noncoding RNAs as novel biomarkers in chronic kidney disease,” RNA, vol. 23, no. 2, pp. 142–152, 2017. View at Publisher · View at Google Scholar
  23. I. Z. Ben-Dov, T. Muthukumar, P. Morozov, F. B. Mueller, T. Tuschl, and M. Suthanthiran, “MicroRNA sequence profiles of human kidney allografts with or without tubulointerstitial fibrosis,” Transplantation, vol. 94, pp. 1086–1094, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. A. H. Van Craenenbroeck, E. M. Van Craenenbroeck, A. K. Van et al., “Impaired vascular function contributes to exercise intolerance in chronic kidney disease,” Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association, vol. 31, no. 12, pp. 2064–2072, 2016. View at Publisher · View at Google Scholar
  25. T. Pisitkun, R. F. Shen, and M. A. Knepper, “Identification and proteomic profiling of exosomes in human urine,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, p. 13368, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. B. S. Zitkus, “American Diabetes Association Standards of Medical Care in Diabetes,” Nurse Practitioner, vol. 30, pp. S12–S54, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Wang, S. Gu, H. Cao et al., “miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis,” SCI REP-UK, vol. 6, article 30122, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. E. Flowers, M. Gadgil, B. E. Aouizerat, and A. M. Kanaya, “Circulating microRNAs associated with glycemic impairment and progression in Asian Indians,” Biomarker Research, vol. 3, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  29. J. Muralidharan, A. Ramezani, M. Hubal et al., “Extracellular microRNA signature in chronic kidney disease,” American Journal of Physiology - Renal Physiology, vol. 312, no. 6, pp. F982–F991, 2016. View at Publisher · View at Google Scholar
  30. X. Meng, D. J. Nikolic-Paterson, and H. Y. Lan, “TGF-β: the master regulator of fibrosis,” Nature Reviews. Nephrology, vol. 12, no. 6, pp. 325–338, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Wang, J. C. Jha, S. Hagiwara et al., “Transforming growth factor-beta1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b,” Kidney International, vol. 85, pp. 352–361, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Wang, Y. Gao, M. Ma et al., “Effect of miR-21 on renal fibrosis by regulating MMP-9 and TIMP1 in kk-ay diabetic nephropathy mice,” Cell Biochemistry and Biophysics, vol. 67, pp. 537–546, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. X. J. Liu, Q. Hong, Z. Wang, Y. Y. Yu, X. Zou, and L. H. Xu, “MicroRNA21 promotes interstitial fibrosis via targeting DDAH1: a potential role in renal fibrosis,” Molecular and Cellular Biochemistry, vol. 411, pp. 181–189, 2016. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Bao, S. Hu, C. Zhang et al., “Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy,” Biochemical and Biophysical Research Communications, vol. 444, pp. 455–460, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Du, B. Fan, H. Han et al., “NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy,” Kidney International, vol. 84, p. 265, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Zhou, S. A. Hasni, P. Perez et al., “miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1,” Journal of the American Society of Nephrology, vol. 24, pp. 1073–1087, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Eissa, M. Matboli, and M. M. Bekhet, “Clinical verification of a novel urinary microRNA panal: 133b, −342 and −30 as biomarkers for diabetic nephropathy identified by bioinformatics analysis,” Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol. 83, pp. 92–99, 2016. View at Publisher · View at Google Scholar · View at Scopus
  38. J. Lu, B. C. Kwan, F. M. Lai et al., “Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis,” Nephrology, vol. 17, pp. 346–351, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. I. Z. Bendov, Y. C. Tan, P. Morozov et al., “Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline,” PLoS One, vol. 9, article e86856, 2013. View at Publisher · View at Google Scholar · View at Scopus
  40. D. K. Singh, P. Winocour, and K. Farrington, “Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathy,” Nature Clinical Practice. Nephrology, vol. 4, pp. 216–226, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Kato, H. Yuan, Z. G. Xu et al., “Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease,” Journal of the American Society of Nephrology, vol. 17, pp. 3325–3335, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. Z. Z. Jiang, G. Y. Xia, and Z. K. Xiong, “Application of ultrasound-microbubble-mediated gene transfer in the treatment of tissue fibrosis,” Chinese Journal of Medical Imaging Technology, vol. 26, no. 5, pp. 983–985, 2010. View at Google Scholar
  43. X. Zhong, A. C. Chung, H. Y. Chen et al., “miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes,” Diabetologia, vol. 56, p. 663, 2013. View at Publisher · View at Google Scholar · View at Scopus