Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2017 (2017), Article ID 7047909, 6 pages
Research Article

Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study

1Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea
2Department of Internal Medicine, Busan St. Mary’s Medical Center, Busan, Republic of Korea
3Department of Internal Medicine, Woori Medical Clinic, Busan, Republic of Korea
4Department of Internal Medicine, Bongseng Memorial Hospital, Busan, Republic of Korea
5Department of Internal Medicine, Ilsin Christian Hospital, Busan, Republic of Korea
6Department of Internal Medicine, Good Moonhwa Hospital, Busan, Republic of Korea
7Department of Internal Medicine, Daedong Hospital, Busan, Republic of Korea
8Department of Internal Medicine, College of Medicine, Pusan Paik Hospital, Inje University, Busan, Republic of Korea

Correspondence should be addressed to Sang Soo Kim and In Joo Kim

Received 29 November 2016; Revised 17 April 2017; Accepted 18 May 2017; Published 16 August 2017

Academic Editor: Andrea Tura

Copyright © 2017 Jong Ho Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. The aim of this study was to evaluate the association between arterial stiffness and albuminuria and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus. Methods. This multicenter cohort study analyzed 2613 patients with type 2 diabetes. Brachial-ankle pulse wave velocity (baPWV) was used as a noninvasive marker of arterial stiffness. Additionally, the patients were categorized into four groups according to their albumin-to-creatinine ratio (ACR, normoalbuminuria versus albuminuria) and estimated GFR (eGFR, <60 mL/min/1.73 m2 versus ≥60 mL/min/1.73 m2). Results. A univariate analysis revealed that maximal baPWV was significantly associated with both the ACR (, ) and eGFR (, ). A multivariate analysis adjusted for significant clinical variables and eGFR showed that baPWV remained significantly correlated with the ACR (, ). Also, baPWV was correlated positively with the ACR in patients with an eGFR ≥ 60 mL/min/1.73 m2 (, ). However, baPWV was not correlated with eGFR after adjustment for significant clinical variables. Conclusions. The present findings indicate that arterial stiffness is more associated with albuminuria than a decrease in GFR in patients with type 2 diabetes mellitus.