SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models

Figure 3

The role of SIRT1 in cognition and learning and memory under the condition of IR. SIRT1 has been shown to increase neurite outgrowth by activating the PI3K/Akt pathway and improve mitochondrial function through the AMPK/PGC-1α and NeuroD6/PGC-1α pathways. PI3K: phosphoinositide 3-kinase; AMPK: adenosine monophosphate-activated protein kinase; PGC-1α: PPARγ coactivator 1-α; NeuroD6: neuronal differentiation 6.