Research Article

Diosgenin, a Novel Aldose Reductase Inhibitor, Attenuates the Galactosemic Cataract in Rats

Figure 2

Effects of diosgenin on LECs osmotic expansion induced by 50 mM galactose. (a) Primary culture of beagle dog LECs, P1 and P4 represent the 1st and 4th passage, respectively. (b) Effects of diosgenin (DG) on LECs’ osmotic expansion (tiny vacuoles) induced by galactose (50 mM). (c) Effects of DG on LECs’ cellular viability. (d) Effects of DG on AR mRNA expression. Values are mean ± SD, , versus the normal group, , , and versus the control group.