Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease

Figure 3

Model showing the modulation of 5-HT2cR in DM. 5-HT2CR-deficient mice showed that 5-HT may affect glucose and lipid metabolism. Insulin secretion is affected by 5-HT2CR, which is indicative of the possibility that an aberrant 5-HT system could also affect the regulation of energy metabolism. Increased expression of 5-HT2CR in both the hypothalamus and β-cells could mediate a protective strategy to prevent excess energy intake. 5-HT2CR-expressing pro-opiomelanocortin neurons are required to control energy and glucose homeostasis.