Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients

Table 3

The significant KEGG pathways for the DEGs of DPN versus DM.

	KEGG pathway	Count	Benjamini value
Upregulated	hsa05164: influenza A	25	0.001
	hsa05162: measles	21	0.001
	hsa00020: citrate cycle (TCA cycle)	9	0.008
	hsa05168: herpes simplex infection	23	0.009
Downregulated	hsa04722: neurotrophin signaling pathway	21	0.001
	hsa04010: MAPK signaling pathway	31	0.003
	hsa04668: TNF signaling pathway	18	0.003
	hsa04380: osteoclast differentiation	20	0.003
	hsa05169: Epstein-Barr virus infection	25	0.003
	hsa05166: HTLV-I infection	30	0.003
	hsa04660: T cell receptor signaling pathway	16	0.010
	hsa05215: prostate cancer	14	0.020
	hsa05142: Chagas disease (American trypanosomiasis)	15	0.029
	hsa05145: toxoplasmosis	16	0.031
	hsa04068: FoxO signaling pathway	17	0.039
	hsa04064: NF-kappa B signaling pathway	13	0.039
	hsa04621: NOD-like receptor signaling pathway	10	0.040