Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients

Table 5

The significant KEGG pathways for the DEGs of different groups.

	KEGG pathway	Count	Benjamini value
DM	hsa04210: apoptosis	32	0.009
	hsa04620: Toll-like receptor signaling pathway	35	0.007
	hsa04144: endocytosis	53	0.014
	hsa04666: Fc gamma R-mediated phagocytosis	32	0.014
	hsa04062: chemokine signaling pathway	53	0.013
	hsa04662: B cell receptor signaling pathway	26	0.024
	hsa04910: insulin signaling pathway	39	0.044
DPN	hsa04662: B cell receptor signaling pathway	39	0.000
	hsa04210: apoptosis	40	0.004
	hsa04621: NOD-like receptor signaling pathway	31	0.004
	hsa04144: endocytosis	69	0.009
	hsa04620: Toll-like receptor signaling pathway	41	0.032
	hsa04142: lysosome	46	0.028
	hsa00280: valine, leucine, and isoleucine degradation	22	0.026
	hsa00520: amino sugar and nucleotide sugar metabolism	22	0.026
DPN versus DM	hsa04010: MAPK signaling pathway	53	0.001
	hsa04621: NOD-like receptor signaling pathway	18	0.016
	hsa04722: neurotrophin signaling pathway	27	0.029