Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondria Apoptosis Pathway

<div>HDAC inhibition attenuated mitochondria-associated apoptosis in diabetic rats. (a) Representative electron micrographs of each group (×7000). (b) Representative TUNEL staining images of each group. (c) Quantitative analysis of the apoptosis rate in each group. (d, e) Representative immune blot images and assessment of the cytochrome C (cytc), Bcl-2, and Bax level in each group. (f, g) Representative immune blot images and assessment of activated and inactivated caspase-3 in cardiac tissue. 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Journal of Diabetes Research

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Figure 4

Figure 4: Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondria Apoptosis Pathway 

Figure 4 | Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondria Apoptosis Pathway 