Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia

Table 1

Subject demographics and inclusion and exclusion criteria for subjects.

Subject demographics
Age	56.2 ± 2.7 years
Gender distribution	5 male and 1 female participants
Height (m)	1.64 ± 0.04
Weight (kg)	66.7 ± 6.0
BMI (kg/m^2)	24.5 ± 1.5
Time since diagnosis (years)	7.8 ± 1.4
Diabetes treatment	Metformin ()
HbA1c (%)/mmol/mol	9.4 ± 0.3/78.9 ± 3.8
Fasting blood glucose (mmol/l)	11.3 ± 0.6
Predicted RMR (Schofield equations) [21] (MJ/d)	6.36 ± 0.31
Calculated RMR (MJ/d)	5.31 ± 1.15
VO2 peak (ml/kg/min)	28.7 (82 ± 4% of the predicted values for healthy; individuals of similar age)
Inclusion criteria	Exclusion criteria
Type 2 diabetes diagnosed >2 yrs before consent	History of cardiac disease
Age 40–69 years inclusive	History of cerebrovascular events or transient ischemic episodes
BMI: <30 kg/m^2	History of intermittent claudication
Suboptimal glycaemic control: HbA1c > 8% (64 mmol/mol)	Significant hypertension defined as a systolic BP > 170 mmHg; and/or diastolic BP > 95 mmHg
Evidence of recent, regular moderate physical activity; (PAL of 1.6–1.7) [22]	Any other disease likely to affect the ability to exercise including; arthritis and respiratory disease
Normal resting 12-lead ECG	Any cardiorespiratory drugs other than thiazide diuretics, aspirin,; ACE-inhibitors, and statins
No significant ECG changes or chest pain during a Bruce; protocol exercise ECG to stage III with a normal physiological; response to exercise	Secondary complications: any diabetic retinopathy other; than mild background retinopathy, nephropathy; (proteinuria on >1 occasion or raised creatinine), and sensory neuropathy

Data are presented as mean ± SEM.