Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes

Table 2

Correlations between serum ANGPTL8 and metabolic parameters in 129 subjects.

(a)

	Model	Age		BMI		Waist circumferences		WHR		SBP
		r		r		r		r		r
ANGPTL8	1	0.067	0.453	0.139	0.117	0.191	0.031	0.195	0.027	0.112	0.208
	2	—	—	—	—	0.132	0.142	0.140	0.120	0.118	0.188
Fasting C-peptide	1	−0.115	0.199	0.387	0.000	0.404	0.000	0.251	0.004	0.047	0.600
	2	—	—	—	—	0.174	0.052	0.096	0.287	−0.029	0.751

(b)

	Model	DBP		TC		TG		LDL-C		HDL-C
		r		r		r		r		r
ANGPTL8	1	−0.014	0.872	0.035	0.692	0.093	0.296	0.058	0.512	0.041	0.648
	2	−0.040	0.659	0.014	0.875	−0.087	0.335	0.039	0.662	0.039	0.669
Fasting C-peptide	1	0.140	0.117	0.163	0.067	0.401	0.000	−0.013	0.884	0.016	0.862
	2	0.010	0.913	0.147	0.102	0.152	0.090	−0.012	0.893	0.025	0.781

(c)

	Model	HBA1C		FPG		PPG		FINS
		r		r		r		r
ANGPTL8	1	−0.094	0.290	0.253	0.004	0.017	0.846	0.334	0.000
	2	0.052	0.567	0.198	0.027	0.066	0.468	0.116	0.197
Fasting C-peptide	1	0.011	0.898	0.241	0.006	0.215	0.015	0.881	0.000
	2	0.035	0.699	0.176	0.049	0.138	0.126	0.829	0.000

(d)

	Model	Fasting C-peptide		PINS		Postprandial C-peptide		HOMA-IR
		r		r		r		r
ANGPTL8	1	0.218	0.013	0.271	0.002	0.196	0.026	0.355	0.000
	2	0.204	0.022	0.093	0.305	0.177	0.049	0.135	0.134
Fasting C-peptide	1	—	—	0.701	0.000	0.665	0.000	0.874	0.000
	2	—	—	0.389	0.000	0.642	0.000	0.781	0.000

(e)

	Model	HOMA-BETA		BETA/IR		ΔI120/ΔG120		ΔI120/ΔG120/IR
		r		r		r		r
ANGPTL8	1	0.140	0.113	−0.252	0.004	0.127	0.153	−0.063	0.478
	2	0.033	0.713	−0.275	0.002	−0.023	0.799	−0.059	0.514
Fasting C-peptide	1	0.673	0.000	−0.240	0.006	0.331	0.000	−0.119	0.182
	2	0.605	0.000	−0.299	0.001	0.141	0.117	0.012	0.894

Model 2: adjusted for age and BMI. — means the analysis was not performed.