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Journal of Diabetes Research
Volume 2017 (2017), Article ID 8314852, 8 pages
https://doi.org/10.1155/2017/8314852
Review Article

Enhancing Exercise Responsiveness across Prediabetes Phenotypes by Targeting Insulin Sensitivity with Nutrition

1Department of Kinesiology, University of Virginia, Charlottesville, VA, USA
2Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA, USA
3Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA

Correspondence should be addressed to Steven K. Malin; ude.ainigriv@n6mks

Received 4 July 2017; Accepted 12 November 2017; Published 13 December 2017

Academic Editor: Maria Pia Francescato

Copyright © 2017 Julian M. Gaitan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Guariguata, D. R. Whiting, I. Hambleton, J. Beagley, U. Linnenkamp, and J. E. Shaw, “Global estimates of diabetes prevalence for 2013 and projections for 2035,” Diabetes Research and Clinical Practice, vol. 103, no. 2, pp. 137–149, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. American Diabetes Association, “2. Classification and Diagnosis of Diabetes,” Diabetes Care, vol. 38, Supplement 1, pp. S8–S16, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. V. A. Fonseca, “Defining and characterizing the progression of type 2 diabetes,” Diabetes Care, vol. 32, Supplement 2, pp. S151–S156, 2009. View at Publisher · View at Google Scholar
  4. C. Meyer, W. Pimenta, H. J. Woerle et al., “Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans,” Diabetes Care, vol. 29, no. 8, pp. 1909–1914, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. W. C. Knowler, E. Barrett-Connor, S. E. Fowler et al., “Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin,” The New England Journal of Medicine, vol. 346, no. 6, pp. 393–403, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. S. K. Malin, J. M. Haus, T. P. J. Solomon, A. Blaszczak, S. R. Kashyap, and J. P. Kirwan, “Insulin sensitivity and metabolic flexibility following exercise training among different obese insulin-resistant phenotypes,” American Journal of Physiology - Endocrinology and Metabolism, vol. 305, no. 10, pp. E1292–E1298, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. T. P. J. Solomon, S. K. Malin, K. Karstoft, J. M. Haus, and J. P. Kirwan, “The influence of hyperglycemia on the therapeutic effect of exercise on glycemic control in patients with type 2 diabetes mellitus,” JAMA Internal Medicine, vol. 173, no. 19, pp. 1834–1836, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Bouchard, S. N. Blair, T. S. Church et al., “Adverse metabolic response to regular exercise: is it a rare or common occurrence?” PLoS One, vol. 7, no. 5, article e37887, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. D. J. Green, T. Eijsvogels, Y. M. Bouts et al., “Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors,” Journal of Applied Physiology, vol. 117, no. 4, pp. 345–352, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Thalacker-Mercer, M. Stec, X. Cui, J. Cross, S. Windham, and M. Bamman, “Cluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy,” Physiological Genomics, vol. 45, no. 12, pp. 499–507, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Alvarez, R. Ramirez-Campillo, R. Ramirez-Velez, and M. Izquierdo, “Prevelance of non-responders for glucose control markers after 10 weeks of high intensity interval training in adult women with higher and lower insulin resistance,” Frontiers in Physiology, vol. 8, p. 479, 2017. View at Publisher · View at Google Scholar
  12. R. Blanco-Rojo, J. F. Alcala-Diaz, S. Wopereis et al., “The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2 years of intervention: the CORDIOPREV-DIAB randomised clinical trial,” Diabetologia, vol. 59, no. 1, pp. 67–76, 2016. View at Publisher · View at Google Scholar · View at Scopus
  13. F. L. Burton, D. Malkova, M. J. Caslake, and J. M. R. Gill, “Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men,” International Journal of Obesity, vol. 32, no. 3, pp. 481–489, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. A. R. Assali, A. Ganor, Y. Beigel, Z. Shafer, T. Hershcovici, and M. Fainaru, “Insulin resistance in obesity: body-weight or energy balance?” The Journal of Endocrinology, vol. 171, no. 2, pp. 293–298, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. S. E. Black, E. Mitchell, P. S. Freedson, S. R. Chipkin, and B. Braun, “Improved insulin action following short-term exercise training: role of energy and carbohydrate balance,” Journal of Applied Physiology, vol. 99, no. 6, pp. 2285–2293, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. P. J. Arciero, M. D. Vukovich, J. O. Holloszy, S. B. Racette, and W. M. Kohrt, “Comparison of short-term diet and exercise on insulin action in individuals with abnormal glucose tolerance,” Journal of Applied Physiology, vol. 86, no. 6, pp. 1930–1935, 1999. View at Google Scholar
  17. E. P. Weiss, S. B. Racette, D. T. Villareal et al., “Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial,” The American Journal of Clinical Nutrition, vol. 84, no. 5, pp. 1033–1042, 2006. View at Google Scholar
  18. D. E. Larson-Meyer, L. K. Heilbronn, L. M. Redman et al., “Effect of calorie restriction with or without exercise on insulin sensitivity, β-cell function, fat cell size, and ectopic lipid in overweight subjects,” Diabetes Care, vol. 29, no. 6, pp. 1337–1344, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. A. D. Arad, F. J. DiMenna, N. Thomas et al., “High-intensity interval training without weight loss improves exercise but not basal or insulin-induced metabolism in overweight/obese African American women,” Journal of Applied Physiology, vol. 119, no. 4, pp. 352–362, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. K. R. Segal, A. Edano, A. Abalos et al., “Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men,” Journal of Applied Physiology, vol. 71, no. 6, pp. 2402–2411, 1991. View at Google Scholar
  21. R. Ross, D. Dagnone, P. J. Jones et al., “Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men: a randomized, controlled trial,” Annals of Internal Medicine, vol. 133, no. 2, pp. 92–103, 2000. View at Publisher · View at Google Scholar
  22. T. P. J. Solomon, S. N. Sistrun, R. K. Krishnan et al., “Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults,” Journal of Applied Physiology, vol. 104, no. 5, pp. 1313–1319, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. J. M. Haus, T. P. Solomon, C. M. Marchetti, J. M. Edmison, F. Gonzalez, and J. P. Kirwan, “Free fatty acid-induced hepatic insulin resistance is attenuated following lifestyle intervention in obese individuals with impaired glucose tolerance,” The Journal of Clinical Endocrinology & Metabolism, vol. 95, no. 1, pp. 323–327, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. J. F. P. Wojtaszewski, J. N. Nielsen, and E. A. Richter, “Invited review: effect of acute exercise on insulin signaling and action in humans,” Journal of Applied Physiology, vol. 93, no. 1, pp. 384–392, 2002. View at Publisher · View at Google Scholar
  25. A. Sparti and J. Decombaz, “Effect of diet on glucose tolerance 36 hours after glycogen-depleting exercise,” European Journal of Clinical Nutrition, vol. 46, no. 6, pp. 377–385, 1992. View at Google Scholar
  26. K. A. Holtz, B. R. Stephens, C. G. Sharoff, S. R. Chipkin, and B. Braun, “The effect of carbohydrate availability following exercise on whole-body insulin action,” Applied Physiology, Nutrition, and Metabolism, vol. 33, no. 5, pp. 946–956, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. B. R. Stephens, J. M. Sautter, K. A. Holtz, C. G. Sharoff, S. R. Chipkin, and B. Braun, “Effect of timing of energy and carbohydrate replacement on post-exercise insulin action,” Applied Physiology, Nutrition, and Metabolism, vol. 32, no. 6, pp. 1139–1147, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. G. D. Cartee, D. A. Young, M. D. Sleeper, J. Zierath, H. Wallberg-Henriksson, and J. O. Holloszy, “Prolonged increase in insulin-stimulated glucose transport in muscle after exercise,” American Journal of Physiology - Endocrinology and Metabolism, vol. 256, no. 4, pp. E494–E499, 1989. View at Google Scholar
  29. J. F. Horowitz, A. E. Kaufman, A. K. Fox, and M. P. Harber, “Energy deficit without reducing dietary carbohydrate alters resting carbohydrate oxidation and fatty acid availability,” Journal of Applied Physiology, vol. 98, no. 5, pp. 1612–1618, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. S. A. Newsom, S. Schenk, K. M. Thomas et al., “Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity,” Journal of Applied Physiology, vol. 108, no. 3, pp. 554–560, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. B. H. Goodpaster, A. Katsariaras, and D. E. Kelley, “Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity,” Diabetes, vol. 52, no. 9, pp. 2191–2197, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Lattuada, F. Costantino, A. Caumo et al., “Reduced whole-body lipid oxidation is associated with insulin resistance, but not with intramyocellular lipid content in offspring of type 2 diabetic patients,” Diabetologia, vol. 48, no. 4, pp. 741–747, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. M. C. Venables and A. E. Jeukendrup, “Endurance training and obesity: effect on substrate metabolism and insulin sensitivity,” Medicine and Science in Sports and Exercise, vol. 40, no. 3, pp. 495–502, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. B. Braun, C. Sharoff, S. R. Chipkin, and F. Beaudoin, “Effects of insulin resistance on substrate utilization during exercise in overweight women,” Journal of Applied Physiology, vol. 97, no. 3, pp. 991–997, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Kang, D. E. Kelley, R. J. Robertson et al., “Substrate utilization and glucose turnover during exercise of varying intensities in individuals with NIDDM,” Medicine & Science in Sports & Exercise, vol. 31, no. 1, pp. 82–89, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. S. K. Malin, R. Viskochil, C. Oliver, and B. Braun, “Mild fasting hyperglycemia shifts fuel reliance toward fat during exercise in adults with impaired glucose tolerance,” Journal of Applied Physiology, vol. 115, no. 1, pp. 78–83, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. S. K. Malin, T. P. J. Solomon, A. Blaszczak, S. Finnegan, J. Filion, and J. P. Kirwan, “Pancreatic β-cell function increases in a linear dose-response manner following exercise training in adults with prediabetes,” American Journal of Physiology - Endocrinology and Metabolism, vol. 305, no. 10, pp. E1248–E1254, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. M. A. Abdul-Ghani, M. Molina-Carrion, R. Jani, C. Jenkinson, and R. A. DeFronzo, “Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin,” Acta Diabetologica, vol. 45, no. 3, pp. 147–150, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Harrison, D. J. O’Gorman, N. McCaffrey et al., “Influence of acute exercise with and without carbohydrate replacement on postprandial lipid metabolism,” Journal of Applied Physiology, vol. 106, no. 3, pp. 943–949, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. E. C. Freese, A. S. Levine, D. P. Chapman, D. B. Hausman, and K. J. Cureton, “Effects of acute sprint interval cycling and energy replacement on postprandial lipemia,” Journal of Applied Physiology, vol. 111, no. 6, pp. 1584–1589, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. G. Boden, “Role of fatty acids in the pathogenesis of insulin resistance and NIDDM,” Diabetes, vol. 46, no. 1, pp. 3–10, 1997. View at Publisher · View at Google Scholar
  42. G. Boden and X. Chen, “Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes,” The Journal of Clinical Investigation, vol. 96, no. 3, pp. 1261–1268, 1995. View at Publisher · View at Google Scholar
  43. G. Boden, X. Chen, J. Ruiz, J. V. White, and L. Rossetti, “Mechanisms of fatty acid-induced inhibition of glucose uptake,” The Journal of Clinical Investigation, vol. 93, no. 6, pp. 2438–2446, 1994. View at Publisher · View at Google Scholar
  44. C. Yu, “Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle,” The Journal of Biological Chemistry, vol. 277, no. 52, pp. 50230–50236, 2002. View at Publisher · View at Google Scholar · View at Scopus
  45. A. K. Fox, A. E. Kaufman, and J. F. Horowitz, “Adding fat calories to meals after exercise does not alter glucose tolerance,” Journal of Applied Physiology, vol. 97, no. 1, pp. 11–16, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. S. Schenk, J. N. Cook, A. E. Kaufman, and J. F. Horowitz, “Postexercise insulin sensitivity is not impaired after an overnight lipid infusion,” American Journal of Physiology - Endocrinology and Metabolism, vol. 288, no. 3, pp. E519–E525, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. B. H. Goodpaster, J. He, S. Watkins, and D. E. Kelley, “Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes,” The Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 12, pp. 5755–5761, 2001. View at Publisher · View at Google Scholar
  48. D. E. Kelley and L. J. Mandarino, “Fuel selection in human skeletal muscle in insulin resistance: a reexamination,” Diabetes, vol. 49, no. 5, pp. 677–683, 2000. View at Publisher · View at Google Scholar
  49. K. Van Proeyen, K. Szlufcik, H. Nielens et al., “Training in the fasted state improves glucose tolerance during fat-rich diet,” The Journal of Physiology, vol. 588, no. 21, pp. 4289–4302, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. A. E. Jeukendrup, “Periodized nutrition for athletes,” Sports Medicine, vol. 47, Supplement 1, pp. 51–63, 2017. View at Publisher · View at Google Scholar
  51. A. B. Evert, J. L. Boucher, M. Cypress et al., “Nutrition therapy recommendations for the management of adults with diabetes,” Diabetes Care, vol. 37, Supplement 1, pp. S120–S143, 2014. View at Publisher · View at Google Scholar · View at Scopus
  52. C. Visuthranukul, P. Sirimongkol, A. Prachansuwan, C. Pruksananonda, and S. Chomtho, “Low-glycemic index diet may improve insulin sensitivity in obese children,” Pediatric Research, vol. 78, no. 5, pp. 567–573, 2015. View at Publisher · View at Google Scholar · View at Scopus
  53. T. P. Solomon, J. M. Haus, K. R. Kelly et al., “Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans,” The American Journal of Clinical Nutrition, vol. 90, no. 5, pp. 1222–1229, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. M. Abdul-Ghani, R. A. DeFronzo, and J. Amin, “Prediabetes and risk of diabetes and associated complications,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 19, no. 5, pp. 394–399, 2016. View at Publisher · View at Google Scholar · View at Scopus
  55. J. P. Kirwan, H. Barkoukis, L. M. Brooks, C. M. Marchetti, B. P. Stetzer, and F. Gonzalez, “Exercise training and dietary glycemic load may have synergistic effects on insulin resistance in older obese adults,” Annals of Nutrition & Metabolism, vol. 55, no. 4, pp. 326–333, 2009. View at Publisher · View at Google Scholar · View at Scopus
  56. T. P. Solomon, J. M. Haus, K. R. Kelly et al., “A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans,” The American Journal of Clinical Nutrition, vol. 92, no. 6, pp. 1359–1368, 2010. View at Publisher · View at Google Scholar · View at Scopus
  57. K. Færch, K. Borch-Johnsen, J. J. Holst, and A. Vaag, “Pathophysiology and aetiology of impaired fasting glycaemia and impaired glucose tolerance: does it matter for prevention and treatment of type 2 diabetes?” Diabetologia, vol. 52, no. 9, pp. 1714–1723, 2009. View at Publisher · View at Google Scholar · View at Scopus
  58. S. K. Malin, N. Niemi, T. P. J. Solomon et al., “Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults,” Annals of Nutrition & Metabolism, vol. 61, no. 2, pp. 135–141, 2012. View at Publisher · View at Google Scholar · View at Scopus
  59. S. H. Cheong, L. J. McCargar, B. W. Paty, C. Tudor-Locke, and R. C. Bell, “The first step first bite program: guidance to increase physical activity and daily intake of low–glycemic index foods,” Journal of the American Dietetic Association, vol. 109, no. 8, pp. 1411–1416, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. E. Q. Ye, S. A. Chacko, E. L. Chou, M. Kugizaki, and S. Liu, “Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain,” The Journal of Nutrition, vol. 142, no. 7, pp. 1304–1313, 2012. View at Publisher · View at Google Scholar · View at Scopus
  61. T. Wirstrom, A. Hilding, G. HF, C.-G. Ostenson, and A. Bjorklund, “Consumption of whole grain reduces risk of deteriorating glucose tolerance, including progression to prediabetes,” The American Journal of Clinical Nutrition, vol. 97, no. 1, pp. 179–187, 2013. View at Publisher · View at Google Scholar · View at Scopus
  62. J. P. Kirwan, S. K. Malin, A. R. Scelsi et al., “A whole-grain diet reduces cardiovascular risk factors in overweight and obese adults: a randomized controlled trial,” The Journal of Nutrition, vol. 146, no. 11, pp. 2244–2251, 2016. View at Publisher · View at Google Scholar · View at Scopus
  63. M. A. Pereira, D. R. Jacobs, J. J. Pins et al., “Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults,” The American Journal of Clinical Nutrition, vol. 75, no. 5, pp. 848–855, 2002. View at Google Scholar
  64. M. G. Priebe, H. Wang, D. Weening, M. Schepers, T. Preston, and R. J. Vonk, “Factors related to colonic fermentation of nondigestible carbohydrates of a previous evening meal increase tissue glucose uptake and moderate glucose-associated inflammation,” The American Journal of Clinical Nutrition, vol. 91, no. 1, pp. 90–97, 2010. View at Publisher · View at Google Scholar · View at Scopus
  65. A. Thorburn, J. Muir, and J. Proietto, “Carbohydrate fermentation decreases hepatic glucose output in healthy subjects,” Metabolism, vol. 42, no. 6, pp. 780–785, 1993. View at Publisher · View at Google Scholar · View at Scopus
  66. K. S. Juntunen, D. E. Laaksonen, K. S. Poutanen, L. K. Niskanen, and H. M. Mykkänen, “High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women,” The American Journal of Clinical Nutrition, vol. 77, no. 2, pp. 385–391, 2003. View at Google Scholar
  67. C. B. Breneman and L. Tucker, “Dietary fibre consumption and insulin resistance – the role of body fat and physical activity,” The British Journal of Nutrition, vol. 110, no. 02, pp. 375–383, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. H. M. Heikkilä, B. Krachler, R. Rauramaa, and U. S. Schwab, “Diet, insulin secretion and insulin sensitivity – the dose–responses to exercise training (DR’s EXTRA) study (ISRCTN45977199),” The British Journal of Nutrition, vol. 112, no. 09, pp. 1530–1541, 2014. View at Publisher · View at Google Scholar · View at Scopus
  69. M. Kanat, D. Winnier, L. Norton et al., “The relationship between β-cell function and glycated hemoglobin: results from the veterans administration epidemiology study,” Diabetes Care, vol. 34, no. 4, pp. 1006–1010, 2011. View at Publisher · View at Google Scholar · View at Scopus
  70. C. L. Rock, S. W. Flatt, B. Pakiz et al., “Weight loss, glycemic control, and cardiovascular disease risk factors in response to differential diet composition in a weight loss program in type 2 diabetes: a randomized controlled trial,” Diabetes Care, vol. 37, no. 6, pp. 1573–1580, 2014. View at Publisher · View at Google Scholar · View at Scopus
  71. F. M. Sacks, V. J. Carey, C. A. M. Anderson et al., “Effects of high vs low glycemic index of dietary carbohydrate on cardiovascular disease risk factors and insulin sensitivity,” Journal of the American Medical Association, vol. 312, no. 23, pp. 2531–2541, 2014. View at Publisher · View at Google Scholar · View at Scopus
  72. J. L. Ivy, M. C. Lee, J. T. Brozinick, and M. J. Reed, “Muscle glycogen storage after different amounts of carbohydrate ingestion,” Journal of Applied Physiology, vol. 65, no. 5, pp. 2018–2023, 1988. View at Google Scholar
  73. R. Jentjens and A. E. Jeukendrup, “Determinants of post-exercise glycogen synthesis during short-term recovery,” Sports Medicine, vol. 33, no. 2, pp. 117–144, 2003. View at Publisher · View at Google Scholar · View at Scopus
  74. J. D. MacDougall, G. R. Ward, and J. R. Sutton, “Muscle glycogen repletion after high-intensity intermittent exercise,” Journal of Applied Physiology, vol. 42, no. 2, pp. 129–132, 1977. View at Google Scholar
  75. R. Ross, I. Janssen, J. Dawson et al., “Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial,” Obesity Research, vol. 12, no. 5, pp. 789–798, 2004. View at Publisher · View at Google Scholar