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Journal of Diabetes Research
Volume 2017, Article ID 8356537, 10 pages
Review Article

The LDL Receptor-Related Protein 1: At the Crossroads of Lipoprotein Metabolism and Insulin Signaling

1Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, USA
2Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
3Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA

Correspondence should be addressed to Selen C. Muratoglu; ude.dnalyramu.mos@ainatacs

Received 3 March 2017; Accepted 11 April 2017; Published 11 May 2017

Academic Editor: Paola Llanos

Copyright © 2017 Dianaly T. Au et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The metabolic syndrome is an escalating worldwide public health concern. Defined by a combination of physiological, metabolic, and biochemical factors, the metabolic syndrome is used as a clinical guideline to identify individuals with a higher risk for type 2 diabetes and cardiovascular disease. Although risk factors for type 2 diabetes and cardiovascular disease have been known for decades, the molecular mechanisms involved in the pathophysiology of these diseases and their interrelationship remain unclear. The LDL receptor-related protein 1 (LRP1) is a large endocytic and signaling receptor that is widely expressed in several tissues. As a member of the LDL receptor family, LRP1 is involved in the clearance of chylomicron remnants from the circulation and has been demonstrated to be atheroprotective. Recently, studies have shown that LRP1 is involved in insulin receptor trafficking and regulation and glucose metabolism. This review summarizes the role of tissue-specific LRP1 in insulin signaling and its potential role as a link between lipoprotein and glucose metabolism in diabetes.