Journal of Diabetes Research / 2017 / Article / Tab 1 / Review Article
The LDL Receptor-Related Protein 1: At the Crossroads of Lipoprotein Metabolism and Insulin Signaling Table 1 t 1/2 values calculated from rate constants for LRP1 recycling in cells.
Ligand Cell Condition t 1/2 endocytosis (min)Fold t 1/2 exocytosis (min)Fold a PMFold Ref AF647-α 2 M 3T3-L1 cells Basal 1.69 1.0 6.93 1.0 0.22 1.0 [54 ] AF647-α 2 M 3T3-L1 cells Insulin 1.69 1.0 6.30 0.9 0.24 1.1 [54 ] AF647-α 2 M 3T3-L1 differentiated Basal 2.48 1.5 33.00 4.8 0.07 0.3 [54 ] AF647-α 2 M 3T3-L1 differentiated Insulin 2.04 1.2 16.12 2.3 0.11 0.5 [54 ] 125 I-8G1WI-38 fibroblasts Basal 4.81 2.8 ND ND ND ND [71 ] 125 I-α 2 MHuman SMCs Basal 1.08 0.6 ND ND ND ND b 125 I-α 2 MCHO LRP1 null transfected with chicken LRP1 Basal 2.68 1.6 ND ND ND ND [72 ]
a Fraction of total expressed in plasma membrane [54 ]. b M. Migliorini, S. C. Muratoglu, D. T. Au, and D. K. Strickland, unpublished data. ND: not determined.