Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C

Figure 4

An association of complication and GADA titer with the expression of SUV39H2 and KDM4C in CD4⁺ T lymphocytes from LADA patients was visible. (a) Relative mRNA levels of histone methyltransferase SUV39H2 and demethylase KDM4C in CD4⁺ T lymphocytes from LADA patients, , LADA patients with complications (LADAc, ) versus LADA patients without complications (LADAnc, ). (b) Relative mRNA levels of histone methyltransferase SUV39H2 and demethylase KDM4C in CD4⁺ T lymphocytes from LADA patients, , LADA patients with low GADA titer () versus LADA patients with high GADA titer ().

(a)

(b)