Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury

<div><i>Pictorial presentation of NO production from arginine by nitric oxide synthase (NOS)</i>. FAD: flavin adenine dinucleotide; FMN: flavin mononucleotide; NADPH: nicotinamide-adenine-dinucleotide phosphate; CaM: calmodulin; BH<sub>4</sub>: tetrahydrobiopterin; ASCH: ascorbic acid; DHFR: dihydrofolate reductase; GTPCH: GTP cyclohydrolase I; PTPS: 6-pyruvoyl-tetrahydropterin synthase; SR: sepiapterin reductase.</div>

Journal of Diabetes Research

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Figure 1

Figure 1: Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury 