Transcriptional Profile of Kidney from Type 2 Diabetic db/db Mice

Figure 2

Identification of DEGs in the transcriptional profile from db/db and db/m mice at 22 w old. (a) Signal values are plotted and clustered in a heat map to determine overt differences in the signal between the 2 samples by TAC. (b) Chromosome distribution analysis shows where induced or repressed genes in db/db mice are located in the mouse genome. (c) Fold change calculated using the TAC software is exhibited as a scatter plot. Genes upregulated in db/db mice are shown in red, whereas downregulated genes are shown in green. (d) A fold change for each gene exceeding 1.5-fold change is plotted against significance as calculated by one-way ANOVA in a volcano plot. DEGs within the black boxes are considered for further ontology and pathway analysis.

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