Research Article

Transcriptional Profile of Kidney from Type 2 Diabetic db/db Mice

Table 3

Top 10 enriched pathway terms of DEGs sorted by value (ascending).

GO termOntology sourceTerm value corrected with Bonferroni step downGenes cluster #1Genes cluster #2

Biological oxidationsREACTOME_10.02.2016[Aoc1, BC021614, Cyp17a1, Cyp27b1, Cyp2d22, Cyp2d26, Cyp4a14, Ephx1, Gm10639, Gm3776, Gsto1, Maoa, Maob][Ces2c, Cndp2, Cyp2a4, Cyp51, Cyp7b1]
Bile acid and bile salt metabolismREACTOME_10.02.2016[Abcc3, Gm6614][Akr1c14, Akr1c18, Amacr, Cyp7b1, Slco1a1]
Steroid hormone biosynthesisKEGG_10.02.2016[Cyp17a1, Cyp2d22, Cyp2d26, Ugt2b34][Akr1c18, Cyp7b1, Hsd17b2, Ugt2b37, Ugt2b38]
Bile secretionKEGG_10.02.2016[Abcb1a, Abcb1b, Abcc3, Abcc4, Ephx1, Slc5a1][Slc22a7, Slco1a1]
Metabolism of fat-soluble vitaminsREACTOME_10.02.2016[Apoe, Cyp27b1, Gc, Ttr][Akr1c14, Akr1c18, Ubiad1]
Metapathway biotransformationWikiPathways_10.02.2016[Cyp17a1, Cyp27b1, Ephx1, Gm3776, Gsta4, Gsto1][Chst11, Cyp51, Cyp7b1, Fmo5]
Glutathione conjugationREACTOME_10.02.2016[BC021614, Gm10639, Gm3776, Gsto1][Cndp2]
Generation of second messenger moleculesREACTOME_10.02.2016[Cd3e, Cd3g, Grap2]
Peroxisomal lipid metabolismREACTOME_10.02.2016[Agps, Amacr, Crot]
Cyclin A/B1 associated events during G2/M transitionREACTOME_10.02.2016[Ccnb2, Plk1, Wee1]