Journal of Diabetes Research / 2017 / Article / Tab 1

Review Article

Classification and Differential Diagnosis of Diabetic Nephropathy

Table 1

Diabetic nephropathy is divided into four hierarchical glomerular lesions.

Class Description and criteria

IMild or nonspecific changes on light microscopy and conformed GBM thickening proven by electron microscopy: GBM > 395 nm (female), GBM > 430 nm (male).
IIaMild mesangial expansion in >25% of the observed mesangium;
area of mesangial proliferation < area of capillary cavity.
IIbSevere mesangial expansion in >25% of the observed mesangium.
Area of mesangial proliferation < area of capillary cavity.
IIIAt least one convincing nodular sclerosis (Kimmelstiel-Wilson lesion).
IVAdvanced diabetic glomerulosclerosis in >50% of glomeruli.

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