The Predictive Role of Tooth Extractions, Oral Infections, and hs-C-Reactive Protein for Mortality in Individuals with and without Diabetes: A Prospective Cohort Study of a 12 1/2-Year Follow-Up

Table 2

Age-adjusted univariate Cox analyses for total mortality—individuals with or without diabetes. A 12 1/2-year follow-up of the Oslo II study of 2000.

Risk factors	Total mortality
	Diabetes; n fatal			Nondiabetes; n fatal
	HR	95% CI	value	HR	95% CI	value
Oral health
Total number of extractions, n	1.01	0.99–1.02	0.245	1.01	1.01–1.02	<0.001
Total number of tooth extractions by group, test of trend	1.03	0.93–1.14	0.556	1.04	1.002–1.08	0.042
Total number of tooth extractions by group
1 = 0-1, reference	1.00	—	—	1.00	—	—
2 = 2–4	1.01	0.73–1.39	0.960	0.84	0.75–0.93	0.010
3 = 5–8	0.86	0.57–1.30	0.478	0.86	0.75–0.99	0.033
4 = 9–31	1.14	0.79–1.66	0.477	1.15	1.001–1.32	0.049
5 = 32	1.23	0.67–2.24	0.502	1.49	1.19–1.87	0.001
Tooth extraction by infection (TE)	0.93	0.72–1.21	0.58	1.09	0.996–1.187	0.06
Periodontitis (PI)	1.13	0.74–1.71	0.58	0.997	0.824–1.207	0.98
TE and PI combined (OI)	0.92	0.71–1.20	0.53	1.11	1.02–1.21	0.02
General measurements
Age in 2000 years	1.13	1.09–1.17	<0.01	1.13	1.12–1.14	<0.01
Glucose nonfasting mmol/l	0.995	0.96–1.03	0.73	1.07	1.04–1.10	<0.01
Systolic blood pressure mmHg	1.003	0.997–1.01	0.30	1.004	1.002–1.006	<0.01
BMI Kg/mm^2	0.998	0.96–1.03	0.91	0.995	0.98–1.01	0.44
Total cholesterol mmol/l	1.07	0.95–1.21	0.26	0.93	0.89–0.97	<0.01
Triglycerides mmol/l	1.07	0.97–1.17	0.18	0.996	0.95–1.04	0.858
HDL mmol/l	1.16	0.84–1.59	0.38	0.95	0.88–1.06	0.337
hs-CRP mmol/l; n diabetes 331; n nondiabetes 4662	1.02	1.01–1.03	0.01	1.01	1.004–1.01	<0.01
hs-CRP mmol/l quartile values
1 = 0–0.81, reference	1.00	—	—	1.00	—	—
2 = 0.82–1.67	0.66	0.42–1.05	0.078	1.09	0.94–1.27	0.243
3 = 1.68–3.46	0.72	0.45–1.16	0.181	1.27	1.10–1.47	0.001
4 = 3.47+	1.43	0.94–2.18	0.098	1.84	1.60–2.11	<0.001
Alcohol drinking; 4–7 times per week	0.82	0.62–1.09	0.17	1.10	1.002–1.20	0.045
Daily smoking; Yes	1.25	0.91–1.72	0.17	1.92	1.74–2.11	<0.01
Level of education; 1–12	0.997	0.96–1.03	0.85	0.96	0.95–0.97	<0.01

Bold indicates value <0.05.