Polymorphisms in the Glucagon-Like Peptide 1 Receptor (GLP-1R) Gene Are Associated with the Risk of Coronary Artery Disease in Chinese Han Patients with Type 2 Diabetes Mellitus: A Case-Control Study
Table 2
Distribution of SNP genotype frequencies in CAD-positive and control groups in additive inheritance mode.
SNP
Genotype
CAD-pos. (%)
Controls (%)
rs761387
TT
268 (68.0)
142 (65.4)
1
TC
113 (28.7)
69 (31.8)
0.696
0.855
0.530–1.382
0.523
CC
13 (3.3)
6 (2.8)
1.065
0.277–4.102
0.927
rs2268635
GG
168 (42.6)
109 (50.2)
1
GA
186 (47.2)
88 (40.6)
0.193
1.064
0.666–1.699
0.795
AA
40 (10.2)
20 (9.2)
1.105
0.496–2.458
0.807
rs7769547
GG
102 (25.9)
54 (24.9)
1
GA
208 (52.8)
107 (49.3)
0.446
0.829
0.476–1.445
0.509
AA
84 (21.3)
56 (25.8)
0.750
0.390–1.442
0.388
rs910162
TT
91 (23.1)
57 (26.3)
1
TA
220 (55.8)
105 (48.4)
0.204
1.127
0.653–1.945
0.668
AA
83 (21.1)
55 (25.3)
0.920
0.480–1.764
0.801
rs3765468
GG
268 (68.0)
143 (65.9)
1
GA
112 (28.4)
68 (31.3)
0.683
0888
0.548–1.441
0.632
AA
14 (3.6)
6 (2.8)
1.201
0.317–4.546
0.788
rs3765467
GG
240 (60.9)
143 (65.9)
1
GA
134 (34.0)
65 (30.0)
0.469
0.883
0.553–1.411
0.603
AA
20 (5.1)
9 (4.1)
2.546
0.557–11.64
0.228
rs3765466
AA
67 (17.0)
35 (16.1)
1
AT
204 (51.8)
108 (49.8)
0.766
0.681
0.349–1.330
0.261
TT
123 (31.2)
74 (34.1)
0.833
0.401–1.731
0.625
rs10305456
CC
330 (83.8)
177 (81.6)
1
CT
63 (16.0)
39 (18.0)
0.743
1.114
0.611–2.030
0.725
TT
1 (0.3)
1 (0.5)
/a
/
/
rs10305518
TT
281 (71.3)
155 (71.4)
1
TG
102 (25.9)
57 (26.3)
0.935
0.812
0.487–1.354
0.425
GG
11 (2.8)
5 (2.3)
0.985
0.250–3.887
0.983
rs1820
TT
341 (86.5)
189 (87.1)
1
TA
49 (12.4)
28 (12.9)
0.170
1.165
0.584–2.324
0.665
AA
4 (1.0)
0 (0.0)
/
/
/
rs4714210
AA
173 (43.9)
88 (40.6)
1
AG
193 (49.0)
97 (44.7)
0.01
1.159
0.715–1.878
0.550
GG
28 (7.1)
32 (14.7)
0.475
0.232–0.970
0.041
for the chi-square test using crosstabulation. ORs are odds ratios of each genotype as compared with homozygous for the major allele. Logistical regression was used to calculate ORs, CIs (95% confidence intervals of ORs), and corresponding values (), and all three values are presented after adjustment for gender, age, BMI, smoking status, hyperlipidemia history, hypertension history, and diabetic duration. a,, or could not be acquired because allele frequencies were too small.
