Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

Figure 1

An overview of the layers of the skin and muscle. Upon injection into the subcutaneous compartment, insulin can either be absorbed by blood capillaries (red) and/or lymphatic capillaries (green). Adapted with permission from Taylor & Francis and Frost GI: Recombinant human hyaluronidase (rHuPH20): An enabling platform for subcutaneous drug and fluid administration. Expert Opin Drug Deliv (2007) 4(4):427–440. © 2007 Taylor & Francis.