Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice

Figure 2

Overnight glimepiride treatment has no effect on glucose tolerance. C57Bl/6J mice were treated overnight or for 2 weeks with glimepiride (8 mg/kg/day), then glucose tolerance was assessed. Unlike the 2-week treatment, overnight treatment with glimepiride (8 mg/kg/day) had no effect on either fasting blood glucose (a) or glucose tolerance (b). ; /control, /overnight, weeks. Closed circles = control group; open circles = overnight treatment; inverted triangles = two-week treatment.

(a)

(b)