Research Article
Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice
Figure 3
Glimepiride impairs glucose tolerance in many different strains. We treated a variety of wild-type inbred mice with glimepiride (8 mg/kg/day) or control chow for 2 weeks, then performed a glucose tolerance test. C57Bl/6J (/control, /glimepiride), C57Bl/6N (/group), BalbC (/group), and C3H (/group) mice showed both elevated fasting blood glucose (a) and impaired glucose tolerance (b) when treated with glimepiride. compared with control animals. Black bars = control group; white bars = glimepiride group.
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