Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice

Figure 7

Glimepiride impairs glucose tolerance in db/db mice. We treated the obese, insulin-resistant db/db mouse with glimepiride (1 mg/kg/day). Though blood glucose was not significantly affected at any of the time points during the GTT (a), there was an overall impairment in glucose tolerance (b). /control, /glimepiride. . Closed circles = control; open circles = glimepiride.

(a)

(b)