Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice

Table 1

Mouse strains and treatments.

Strain		Assay	Treatment length	Age (months)
C57Bl/6J	29	GTT	2 weeks	2.5–5
	11	PTT	1.5 months	3.4
	12	ELISAs	1.5 months	3.5
C57Bl/6N	12	GTT	2 weeks	3.7
	11	ITT	1 month	4.2
	12	ELISAs	1.5 months	4.8
C3H	12	GTT	2 weeks	2.4
	12	GTT^†	3 weeks	3
	12	ELISAs	‡	3.1
BalbC	10	GTT	2 weeks	2.4
Grn^−/−	18	GTT	2 weeks	5–10
	10	ELISAs	8 months	21
db/db	11	GTT	2 weeks	4.4

^†Performed after three weeks after removal of glimepiride (wash out). ^‡Blood was collected at endpoint, soon after the three-week wash out.