Research Article
Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice
Table 1
Mouse strains and treatments.
| Strain | | Assay | Treatment length | Age (months) |
| C57Bl/6J | 29 | GTT | 2 weeks | 2.5–5 | 11 | PTT | 1.5 months | 3.4 | 12 | ELISAs | 1.5 months | 3.5 |
| C57Bl/6N | 12 | GTT | 2 weeks | 3.7 | 11 | ITT | 1 month | 4.2 | 12 | ELISAs | 1.5 months | 4.8 |
| C3H | 12 | GTT | 2 weeks | 2.4 | 12 | GTT† | 3 weeks | 3 | 12 | ELISAs | ‡ | 3.1 |
| BalbC | 10 | GTT | 2 weeks | 2.4 |
| Grn−/− | 18 | GTT | 2 weeks | 5–10 | 10 | ELISAs | 8 months | 21 |
| db/db | 11 | GTT | 2 weeks | 4.4 |
|
|
†Performed after three weeks after removal of glimepiride (wash out). ‡Blood was collected at endpoint, soon after the three-week wash out.
|