Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice

Table 2

Rodent glimepiride treatments in previous publications.

Species	Strain	Glimepiride (mg/kg/day)	Route of administration	Length of treatment	Blood glucose	Reference
Mouse	ApoE^−/−	0.1	Oral gavage	8 weeks	Decreased	[40]
	KK-Ay	0.5	Oral gavage	8 weeks	Decreased	[41]
	C57Bl/6	2	Oral gavage	4 weeks	Decreased	[42]
	db/db/C57Bl/6 + STZ	2.5	Oral gavage	6 weeks	Decreased	[43]
	KsJ-db/db	2.5	Oral gavage	4 weeks	Decreased	[44]
	BALB/c	4	i.p.	3 weeks	Decreased	[45]
	Swiss albino + STZ	10	Oral gavage	1 week	Decreased	[46]
Rat	OLETF	0.05	Chow add-mixture	12 weeks	Unchanged	[47]
	Wistar ± STZ	0.09	Oral gavage	<1 day	Decreased	[48]
	Wistar	0.1	Drinking water	4 weeks	n.d.	[32]
	Sprague-Dawley	4	Oral gavage	3 days	n.d.	[49]
	Wistar	5	i.p.	2 days	Unchanged	[50]
	ZDF	5	Oral gavage	12 weeks	Unchanged	[36]
	BB	200	Oral gavage	108 days	Decreased	[51]
	Wistar ± STZ	200	Oral gavage	3 days/8 weeks	Decreased	[52]

i.p. = intraperitoneal injection; n.d. = not determined; OLETF = Otsuka Long-Evans Tokushima fatty; STZ = streptozotocin; ZDF = Zucker diabetic fatty.