Vitamin D Ameliorates Impaired Wound Healing in Streptozotocin-Induced Diabetic Mice by Suppressing Endoplasmic Reticulum Stress

Figure 6

Vitamin D treatment accelerated diabetic wound healing. (a) 6 mm diameter wounds were created by punch biopsy, and the closure of the wound area was measured by digital camera every 3 days until day 14. (b) Percentage of wound closure (means ± SD). Healing of diabetic wounds significantly delayed compared with normal wounds. Vitamin D began to improve diabetic wound closure on day 6. At the end of the observation (day 14), the VD treatment group exhibited improved wound healing, compared with the diabetic group.

(a)

(b)