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Abbrev. | Name | NCBI reference sequence | Potential role in nerve regeneration | Reference |
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BDNF | Brain-derived neurotrophic factor | NM_001709 | Promotion of nerve cell growth and maturation | [14] |
CNTF | Ciliary neurotrophic factor | NG_008776.1 | Expressed in myelinating Schwann cells, nerve regeneration following injury | [10] |
CNTFR | Ciliary neurotrophic factor receptor | NG_047044.1 | [10, 15] |
GALR1 | Galanin receptor 1 | NG_009223.1 | Neuroprotection, neuroregeneration |
GALR2 | Galanin receptor 2 | ā | Neuroprotection, neuroregeneration Expressed in Schwann cells, ensures the response to GDNF | [15, 16] (2002) |
GFRA1 | GDNF family receptor alpha 1 | NG_050620.1 |
GFRA2 | GDNF family receptor alpha 2 | NG_029215.1 | Expressed in Schwann cells, ensures the response to GDNF Essential role in neuronal regeneration | [16ā18, 19] |
GFRA3 | GDNF family receptor alpha 3 | NG_046894.1 |
NGF | Nerve growth factor | NG_007944.1 |
NGFR | Nerve growth factor receptor | NC_000017.11 | Essential role in neuronal regeneration | [19, 20] |
NGFRAP | Nerve growth factor receptor associated protein 1 | NM_0012826741 | Essential role in neuronal regeneration | [19] |
NRG1 | Neuregulin 1 | NG_012005.1 | Family of gliotrophic factors that transduce signal through ErbB receptors and are necessary for Schwann cells growth, survival, and differentiation | [21] |
NRG2 | Neuregulin 2 | NC_000005.10 | Family of gliotrophic factors that transduce signal through ErbB receptors and are necessary for Schwann cells growth, survival, and differentiation Increase of NT-3 appears to reflect the degree of skin denervation in diabetic neuropathy and may represent a compensatory mechanism | [10, 21] |
NRG4 | Neuregulin 4 | NC_000015.10 |
NTF3 | Neurotrophin 3 | NG_050629.1 |
NTF4 | Neurotrophin 4 | NG_016289.1 | Increase of NT-3 appears to reflect the degree of skin denervation in diabetic neuropathy and may represent a compensatory mechanism Essential role in neuronal regeneration | [10, 21, 22] |
NTRK1 | Neurotrophic receptor tyrosine kinase 1 | NG_007493.1 |
NTRK2 | Neurotrophic receptor tyrosine kinase 2 | NG_012201.2 | Essential role in neuronal regeneration | [21, 22] |
TGFA | Transforming growth factor alpha | NG_029975.1 | Trophic factor in both central and peripheral neural tissues | [23] |
NPY | Neuropeptide Y | NG_016148.1 | Increased expression in patients with moderate sensory neuropathy | [24] |
NPY1R | Neuropeptide Y receptor Y1 | NC_000004.12 | Potentially involved in neuronal precursor proliferation |
MPZ | Myelin protein zero | NG_008055.1 | Myelin-specific protein, Schwann cells can modulate this gene expression in response to diabetic-induced metabolic derangement | [25] |
GFAP | Glial fibrillary acidic protein | NG_008401.1 | Glial cell marker | [26] |
FGF2 | Fibroblast growth factor 2 | NG_029067.1 | Expressed by the Schwann cells of the peripheral nerves | [27] |
FGFR1 | Fibroblast growth factor receptor 1 | NG_007729.1 | Secreted by Schwann cells, essential for neuroregeneration | [16, 27, 28] |
GDNF | Glial cell-derived neurotrophic factor | NG_011675.2 | Rapidly responses to denervation produced by basal keratinocytes and Schwann cells |
ERBB2 | erb-b2 receptor tyrosine kinase 2 | NG_007503.1 | Neuregulin receptors, response to chronic denervation, expressed in Schwann cells (26 hoke) | [21, 29] |
ERBB3 | erb-b2 receptor tyrosine kinase 3 | NG_011529.1 | Neuregulin receptors, response to chronic denervation, expressed in Schwann cells | [21, 29] |
ERBB4 | erb-b2 receptor tyrosine kinase 4 | NG_011805.1 |
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