Adipocyte DIO2 Expression Increases in Human Obesity but Is Not Related to Systemic Insulin Sensitivity

Table 2

Correlation coefficients () between adipocyte DIO2 gene expression (fold change) in visceral (VAT) and subcutaneous (SAT) adipose tissue and gene expression of markers of mitochondrial function, fatty acid oxidation/synthesis, and pro- and anti-inflammatory genes.

	VAT DIO2 gene expression ( lean; obese)	SAT DIO2 gene expression ( lean; obese)
Mitochondrial function genes
CIDEA
ATP5A
PGC1α		—
CPT1B
Fatty acid beta-oxidation genes
ACADM
Fatty acid synthesis genes
ACC2
FASN
DGAT
Proinflammatory mediator of gene expression
IL-1β
Leptin
NLRP3
PAI-1
TNFα
Anti-inflammatory Mediator of gene expression
PPARγ
ADIPOQ

ADIPOQ: adiponectin; CIDEA: cell death activator; ATP5A: ATP synthase 5A; CPT1B: carnitine palmitoyltransferase 1B; ACADM: acetyl CoA dehydrogenase; ACC2: acetyl CoA carboxylase; FASN: fatty acid synthase; DGAT: diglyceride acyltransferase; PPARγ: PPARgamma; TNFα: tumor necrosis factor alpha; IL: interleukin; PAI-1: plasminogen activator inhibitor-1. Innate immunity (NLRP3). .