Association of EPHX2 R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients
Table 3
Odds ratios and 95% confidence interval for DN under three genetic models.
Genetic models
Unadjusted
Adjusteda
Adjustedb
OR (95% CI)
OR (95% CI)
OR (95% CI)
Additive
0.69 (0.55–0.86)
<0.001
0.66 (0.52–0.83)
<0.001
0.68 (0.52–0.88)
0.004
Recessive
0.33 (0.18–0.62)
<0.001
0.33 (0.17–0.65)
0.001
0.28 (0.14–0.60)
0.001
Dominant
0.72 (0.55–0.95)
0.018
0.67 (0.50–0.90)
0.008
0.73 (0.53–1.01)
0.059
GA versus GG
0.83 (0.63–1.10)
0.201
0.77 (0.57–1.05)
0.097
0.87 (0.62–1.23)
0.43
AA versus GG
0.31 (0.17–0.58)
<0.001
0.30 (0.15–0.60)
<0.001
0.27 (0.13–0.58)
<0.001
Allele (A versus G)
0.69 (0.55–0.86)
<0.001
CI: confidence interval; DN: diabetic nephropathy; OR: odds ratio. aAdjusted for age and sex. bAdjusted for age, sex, Hcy, BMI, duration of diabetes, hypertension, smoking, total cholesterol, and TG levels.
