Research Article

Association of Metformin Treatment with Reduced Severity of Diabetic Retinopathy in Type 2 Diabetic Patients

Figure 1

Long-term metformin treatment was associated with significantly reduced rate of SNPDR/PDR in type 2 diabetes patients. 25% of 193 metformin users were found to have SNPDR/PDR, while 47% of 142 cases that never used metformin had SNPDR/PDR (). A similar significantly lowered rate of SNPDR/PDR in metformin users versus nonmetformin users was also observed in female (25% versus 53%, ) and male (26% versus 41%, ), as well as in black (31% versus 52%, ) and white (17% versus 38%, ) subgroups. Mil/Mod NPDR: mild and moderate nonproliferative diabetic retinopathy; SNPDR/PDR: severe nonproliferative diabetic retinopathy/proliferative diabetic retinopathy.