Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats

Table 1

Effect of menhaden oil with or without salsalate on weight, chow consumed, serum triglycerides, free fatty acids, and cholesterol in type 2 diabetic Sprague Dawley rats.

Condition	Start weight (g)	End weight (g)	Chow consumed (g/kg body weight/day)	Blood glucose (mg/dl)	Serum triglycerides (mg/ml)	Serum-free fatty acids (mmol/L)	Serum cholesterol (mg/ml)
Control (12)	336 ± 3	494 ± 13	50.5 ± 3.0	147 ± 6	32.7 ± 5.8	0.13 ± 0.02	0.91 ± 0.02
Diabetic (12)	335 ± 2	439 ± 9	58.0 ± 3.8	478 ± 35^a	192.3 ± 18.4^a	0.37 ± 0.05^a	1.95 ± 0.06^a
Diabetic + salsalate (12)	333 ± 3	451 ± 12	48.0 ± 3.5	443 ± 40^a	125.1 ± 25.9	0.36 ± 0.03^a	1.73 ± 0.20^a
Diabetic + menhaden oil 10% (12)	322 ± 3	420 ± 9	48.9 ± 3.3	469 ± 20^a	246.4 ± 30.2^a	0.42 ± 0.06^a	1.53 ± 0.17^a
Diabetic + menhaden oil 10% + salsalate (12)	326 ± 2	439 ± 21	50.9 ± 3.2	396 ± 43^a	102.4 ± 25.0	0.32 ± 0.05^a	1.55 ± 0.17^a
Diabetic + menhaden oil 25% (12)	309 ± 4	426 ± 21	64.5 ± 4.6	500 ± 16^a	316.9 ± 37.5^a	0.41 ± 0.04^a	2.81 ± 0.22^a
Diabetic + menhaden oil 25% + salsalate (12)	305 ± 4	415 ± 14	58.2 ± 3.8	478 ± 39^a	119.4 ± 26.2	0.35 ± 0.03^a	1.78 ± 0.15^a
Diabetic + menhaden oil 45% (12)	335 ± 3	459 ± 18	57.9 ± 4.3	426 ± 42^a	82.6 ± 13.0^a,b	0.40 ± 0.06^a	1.96 ± 0.14^a
Diabetic + menhaden oil 45% + salsalate (12)	315 ± 5	438 ± 14	67.2 ± 5.7	431 ± 35^a	68.9 ± 18.6^b	0.17 ± 0.04	1.33 ± 0.18

Data are presented as the . ^a compared to control rats. ^b compared to diabetic rats. Parentheses indicate the number of experimental animals.