Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat

Table 7

Isolated heart hemodynamic function in the GK rat.

Parameter	Age	Control versus GK	Reference
HR	18 w	237 versus 213 bpm NSF	[31]
	5–8 m	251.8 versus 259.5 bpm NSD	[10]
	9–14 m	267 versus 271 bpm NSD	[11]
	18 m	138 versus 115 bpm NSD	[50]
LVP	18 w	44 versus 52 mmHg NSD	[31]
	6 m	Reduced	[51]
LVDP	5–8 m	126.6 versus 119.8 mmHg NSD	[10]
	6 m	Reduced	[51]
	16 w	NSD	[35]
	9–14 m	76 versus 63 mmHg NSD	[11]
RPP	16 w	NSD	[35]
EDP	9–14 m	8 versus 10 mmHg NSD	[11]
LV +dP/dt	18 w	1365 versus 1602 mmHg/s NSD	[31]
	5–8 m	3390.6 versus 3169.5 mmHg/s NSD	[10]
	6 m	Reduced	[51]
LV −dP/dt	18 w	−945 versus −1032 mmHg/s NSD	[31]
	5–8 m	−2669.0 versus −2672.0 mmHg/s NSD	[10]
	6 m	Reduced	[51]
CF	18 w	7.1 versus 5.8 (ml/min)	[31]
	5–8 m	10.9 versus 9.8 ml/min/g NSD	[10]
	9–14 m	Reduced	[11]
CPP	5–8 m	74.2 versus 76.6 mmHg NSD	[10]

HR: heart rate; LVP: left ventricular pressure; LVDP: left ventricular developed pressure; RPP: rate pressure product; EDP: end diastolic pressure; LV +dP/dt: rate for pressure development in left ventricle; LV –dP/dt: rate for pressure decline in left ventricle; CF: coronary flow; CPP: coronary perfusion pressure; NSD: no significant difference. Significant difference.