Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat

Table 8

Myocyte contraction from the GK rat heart.

Parameter	Age	Control versus GK	Reference
MD	8 w	9.11 versus 9.93 (μm)	[36]
	18 m	9.43 versus 11.34 (μm)	[40]
SA	16 w	Increased	[30]
	6 m	Increased	[51]
CSA	20 w	Increased	[33]
RCL	8–10 w	NSD	[41]
	5–8 m	NSD	[10]
	10 m	139.48 versus 155.63 (μm)	[47]
	10-11 m	Increased	[48]
	17 m	109.7 versus 109.3 μm NSD	[39]
	18 m	139.8 versus 146.4 μm NSD	[50]
CP	14–16 w	Increased	[28]
TPK	8–10 w	115.03 versus 125.38 (ms)	[41]
	10 m	119.77 versus 136.15 (ms)	[47]
	10-11 m	NSD	[48]
	17 m	302.7 versus 337.5 (ms)	[39]
	18 m	119.9 versus 115.1 ms NSD	[50]
THALF	8–10 w	NSD	[41]
	10 m	NSD	[47]
	10-11 m	NSD	[48]
	18 m	75.2 versus 65.1 (ms)	[50]
	17 m	231.3 versus 275.4 (ms)	[39]
AMP	8–10 w	NSD	[41]
	5–8 m	NSD	[10]
	10 m	6.52 versus 7.15% NSD	[47]
	10-11 m	NSD	[48]
	17 m	5.05 versus 6.56 (%)	[39]
	18 m	6.7 versus 6.5% NSD	[50]

MD: myocyte diameter; SA: surface area; CSA: cross-sectional area; RCL: resting cell length; CP: cell capacitance; TPK: time to peak shortening; THALF: time to half relaxation of shortening; AMP: amplitude of shortening; NSD: no significant difference. Significant difference.