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Journal of Diabetes Research
Volume 2018 (2018), Article ID 3082893, 7 pages
Research Article

Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy

1Department of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China
2Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai, China
3Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China
4Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Correspondence should be addressed to Zhiliang Wang and Xiaofang Xu

Received 29 June 2017; Revised 22 September 2017; Accepted 30 October 2017; Published 25 February 2018

Academic Editor: Amany Tawfik

Copyright © 2018 Jing Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To examine the changes in retinal thickness of patients with diabetes without DR. Designs. A randomization, crossover, retrospective practice. Participants. 43 diabetic patients and 43 ethnic-, age-, and sex-matched controls. Methods. Full retinal thicknesses of ten areas were assessed using spectral domain optical coherence tomography. Confounding variables, such as age, gender, and glycated haemoglobin (HbA1c) level, were assessed by regression analysis. Main Outcome Measures. Mean retinal thickness of ten areas. Results. The mean thickness of the fovea was 215.8 ± 18.9 μm in the diabetes group and 222.0 ± 18.6 μm in the control group (). The mean thickness of the temporal parafovea was 319.9 ± 16.7 μm in the diabetes group and 326.0 ± 14.4 μm in the control group (). The mean thickness of the temporal perifovea was 276.4 ± 27.9 μm in the diabetes group and 284.8 ± 17.4 μm in the control group (). There were no significant differences in retinal thickness between groups in other areas (). Regression analysis revealed that decreased retinal thickness of the temporal perifovea was associated with a higher HbA1c level (>8.7%) (). Conclusion and Relevance. Subtle structural changes in the retina may occur in diabetes without DR. Decreased retinal thickness appeared to begin in the fovea and temporal areas. A high HbA1c level was the main factor influencing retinal thickness.