Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet

<div>Non-diet-induced obesity developed stable changes in cells to form abnormal intestinal structures and influenced intestinal cellular homeostasis. (a–c) Intestinal organoids (a) and their budding potential (b, c) decreased in Lep<sup>ob/ob</sup>-derived organoids versus B6 mice. (d–i) mRNA expression of cell death (<i>Bad</i>, <i>Bax</i>, and <i>Bcl2</i>), cell proliferation (Ccnd1, Cdk6, and Sox4), and stem cell- (Lgr5-, Olfm4-, and Bmi1-) specific genes in obese and B6 intestines. 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Journal of Diabetes Research

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Figure 2

Figure 2: Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet 

Figure 2 | Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet 