Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet

Figure 4

Relationship of metabolic functions, intestinal morphology, and functions with gut microbiome dysbiosis, independent of dietary differences. Spearman correlation analysis to establish the association between metabolic measures (body weight, blood glucose, AUC-GTT, and AUC-ITT), gut permeability changes, intestinal structural changes, and gene expression changes and the gut microbiome signature between Lep^ob/ob and B6 mice. Values presented here are average of 3–8 replicates. values are defined as and .