High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Lepr^fa/fa Rats: A New Model of Type 2 Diabetes Mellitus

Table 1

Cardio-metabolic parameters in Wistar rats and WBKDF rats fed either the normal sodium (NS) diet or high sodium (HS) diet for 7 weeks.

	Wistar-NS; ()	Wistar-HS; ()	WBKDF-NS; ()	WBKDF-HS; ()	ANOVA; (Strain)	ANOVA; (Treatment)
Organ weight (% body weight)
Liver weight	2.9 ± 0.1	2.9 ± 0.0	3.8 ± 0.1	3.2 ± 0.1
Pancreas weight	0.4 ± 0.0	0.4 ± 0.0	0.2 ± 0.0	0.2 ± 0.0
Mesenteric fat weight	1.4 ± 0.1	0.9 ± 0.1	2.2 ± 0.1	1.9 ± 0.0
Epididynmal fat weight	1.6 ± 0.1	1.2 ± 0.1	2.9 ± 0.0	2.9 ± 0.1
Heart rate (bpm)	390.6 ± 13.3	395.8 ± 17.9	326.4 ± 5.1	346.3 ± 9.6
SBP (mmHg)	127.9 ± 2.2	151.2 ± 3.9^†	120.7 ± 4.1	192.0 ± 8.2
Blood
Glucose (mg/dL)	115.1 ± 3.5	115.0 ± 4.3	344.8 ± 44.2	127.0 ± 8.8
Insulin (ng/dL)	2.4 ± 0.3	1.2 ± 0.2	15.0 ± 1.5	13.2 ± 0.9
AST (U/L)	67.4 ± 4.0	68.8 ± 7.6	74.6 ± 21.4	50.0 ± 2.7
ALT (U/L)	36.5 ± 2.7	32.1 ± 2.4	109.6 ± 24.3	71.6 ± 8.6
T-CHO (mg/dL)	56.5 ± 2.6	47.5 ± 3.8	95.9 ± 5.7	106.6 ± 10.6
TG (mg/dL)	27.1 ± 4.5	26.8 ± 3.1	304.4 ± 34.7	315.8 ± 36.4
PL (mg/dL)	103.9 ± 2.4	92.9 ± 4.9	206.0 ± 7.8	237.6 ± 13.7
Adiponectin (ng/mL)	1432 ± 84	1716 ± 105	2182 ± 195	2687 ± 65
Urine
Volume (mL/24 h)	6.3 ± 0.5	85.1 ± 1.5	23.8 ± 4.7	108.8 ± 7.5
Glucose (g/24 h)	0.2 ± 0.0	0.0 ± 0.0	127.9 ± 39.5	0.0 ± 0.0

Data are expressed as mean ± SE (). Heart rate and SBP are for rats at 12 weeks of ages. Other parameters are for rats at 13 weeks. versus Wistar rats on the same diet; versus Wistar rats on the same diet; versus the same strain of rat on the NS diet; versus the same strain of rat on the NS diet. SBP: systolic blood pressure, AST: aspartate aminotransferase, ALT: alanine aminotransferase, T-CHO: total cholesterol, TG: triglyceride, PL: phospholipid.